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Clinical Trials in the Netherlands / NCT07036328
Recruiting Not applicable

Transcranial Magnetic Stimulation to Slow Down Cognitive Decline in Alzheimer's Disease

NCT07036328 · tracked via the Priya Life Science Netherlands tracker
Sponsor
Willem de Haan
Phase
Not applicable
Started
2025-04-07
Last updated
2026-05-12

Condition(s) studied

Alzheimer DiseaseAlzheimer Disease, Early Onset

Investigational drug(s) / intervention(s)

repetitive transcranial magnetic stimulationsham repetitive transcranial magnetic stimulation

repetitive transcranial magnetic stimulation: 20 Hz repetitive transcranial magnetic stimulation targeted at the precuneus

sham repetitive transcranial magnetic stimulation: 20 Hz sham repetitive transcranial magnetic stimulation targeted at the precuneus

Study summary

New amyloid-targeting drugs for Alzheimer's disease (AD) offer minimal or unclear efficacy and often cause adverse events, highlighting the need for new therapies. In recent years, repetitive transcranial magnetic stimulation (rTMS) has shown increasing success. A recent randomized, double-blind, sham-controlled, phase 2 demonstrated promising results from a 24-week rTMS treatment protocol targeting the precuneus. This brain region is considered a main hub of the human brain connectome and a prominent area of AD pathology. The results showed stable cognitive performance and increased brain activity in the treatment group, whereas the sham group worsened. A replication study is planned to further investigate the working mechanism of precuneus-rTMS in AD and to improve understanding of its therapeutic potential.

Eligibility

Sex
ALL
Min age
50 Years
Max age
85 Years
Healthy volunteers
No
Inclusion Criteria: * Biomarker-supported Alzheimer's disease (abnormal CSF p-tau/Aβ42 ratio of \> 0.023 or amyloid PET positive). * Between 50 and 85 years old. * Clinical Dementia Rating (CDR) score of 0.5 or 1. * Mini-Mental State Examination (MMSE) score between 18 and 27. * Presence of a caregiver. Exclusion Criteria: * Medical history of neurodegenerative diseases other than AD, stroke, or epilepsy. * Severe psychiatric dysregulation, hampering successful study participation and leading to possible cognitive impairment. Eligibility for participation will be based on clinical evaluation by an expert neurologist and/or psychiatrist. * Extensive cerebrovascular damage on MRI classified as Fazekas level 2 or 3. Patients with abnormalities classified as Fazekas level 3 are excluded. For Fazekas level 2, patient's eligibility for participation will be evaluated by an expert neurologist. * Presence of metal in the head or cranial/thoracic implants, including cochlear implants. * Cholinesterase inhibitors with unstable dosage in the last 2 months. * Extreme claustrophobia or metallic objects in or on the body, preventing MRI and MEG examination. * Previous rTMS treatment (for blinding reasons).

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Amsterdam UMC Amsterdam Netherlands Recruiting

Other trials for the same condition

A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2) Active, not recruiting
Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD) Active, not recruiting
A Study to Assess THN391 in Subjects With Alzheimer's Disease Active, not recruiting
Longitudinal Early-onset Alzheimer's Disease Study Protocol Active, not recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants With Early Alzheimer's Disease Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07036328 on ClinicalTrials.gov ↗ ← All trials in the Netherlands