Ultrasound of the diaphragm: Sonographic parameters of the diaphragm:
* Thickening Fraction (TF); (Diaphragm thickness end-inspiration- Diaphragm thickness end-expiration) / Diaphragm thickness end-expiration. (continuous variable).
* Diaphragm end-expiratory thickness: Diaphragm thickness at end-expiration (continuous variable)
* Diaphragm excursion (DE): diaphragm inspiratory amplitude during deep breathing (continuous variable).
Study summary
The study will be conducted as a single-center, prospective cohort study. The primary objective of this study is to investigate the responsiveness of sonographic parameters of diaphragm to detect change in Borg score for dyspnea during hospitalisation for AECOPD without respiratory acidosis.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Hospitalisation primarily because of severe acute exacerbation of COPD
* COPD, according to GOLD 2018 definition
* Post-bronchodilator FEV1/FVC \< 0,70 and FEV1% \< 80%pred. within last 5 years
Exclusion Criteria:
* Respiratory acidosis (pH \< 7.35 ánd PaCO2 \> 6 kPA)
* Need for (non-)invasive ventilation based on other criteria (e.g. severe hypoxia) upon presentation.
* Established diagnosis of diaphragm diaphragm paralysis.
* Inability for diaphragm imaging (e.g. mechanical ventilation, or unable to follow vocal instructions).
* Those not able or unwilling to give written informed consent.
* Pregnant women
Primary outcome measure(s)
- To investigate the responsiveness of sonographic parameters to detect change in Borg score for dyspnea during hospitalisation for AECOPD without respiratory acidosis. — from admission till hospital discharge (expected median of 5 days based on experience) Correlation between:
* Change in Borg score for dyspnea; defined as score at discharge minus score at admission
* Change in sonographic parameters; defined as score at discharge minus score at admission
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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