Vascular Signature Mapping of Brain Tumor Genotypes

Condition(s) studied

Investigational drug(s) / intervention(s)

Philips Achieva 7T MRI: Regular follow-up MRI on 3T scanner and optional additional scan at 7T MRI.

X-ray (optional): Optional X-ray scan to assess the safety for undergoing an MR examination.

Additional contrast injection: Contrast agent administration for the additional 7T scan (optional).

Question list: Questionnaire for contra-indications for an MR examination.

Study summary

A glioma is a primary brain tumor in adults that is characterized by a highly variable, but overall poor survival. The optimal timing of treatment is in part determined by the expected biological behavior of the tumor. At present the expected biological behavior, determined by the tumor genotype, can only be determined by tissue analysis, which requires brain surgery. Non-invasive and improved diagnostic methods are sought to obtain insight into the molecular profile of the tumor and the expected biological behavior to avoid surgery performed solely for diagnostic purposes. Vascularization is an important aspect of the biological behavior of a primary brain tumor. Tumor vascularization characteristics can be assessed by Magnetic Resonance Imaging (MRI), but with the currently available technology this can only be achieved with unacceptably long scan times. In this proposal, the investigators will develop and optimize a novel MRI protocol to gather a large set of quantitative vascularization parameters within an acceptable scan time. The hypothesis is that from such a 'vascular signature' the tumor genotype can be inferred by means of machine learning.

Eligibility

Primary outcome measure(s)

• Optimized MR protocol — 6 months
  MR protocol optimized for SNR and the ability to obtain vascular information
• Vessel architecture — 4 years
  Structure of vessels and tortuosity
• Cerebral blood volume — 4 years
  To characterize the tumor's vasculature
• Cerebral blood flow — 4 years
  To characterize the tumor's vasculature
• Transit time parameters — 4 years
  Timing parameters used to characterize the tumor vasculature
• Vascular oxygenation level — 4 years
  Oxygen-related parameters that describe the tumor's vasculature

Trial sites (2)

More Leiden University Medical Center trials in the Netherlands

Other trials for the same condition