A prospective non-interventional cohort study at Erasmus MC of adult chronic HIV infected patients of ≥18 years of age who initiate antiretroviral therapy in routine care.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age \>18 years.
* Confirmed HIV-1 or HIV-2 infection
* Judged willing to initiate and adhere to cART by the HIV physician.
Exclusion Criteria:
* Inability to place venous catheters to draw blood.
* Major comorbidities:
1. Severe symptomatic anemia or recent symptomatic cardiovascular event (un-stable angina pectoris, decompensated heart failure, myocardial infarction).
2. The inability to participate due to any other relevant social, environmental,psychological, factors or according to the HIV treating physician's judgement.
Primary outcome measure(s)
To develop a prospective cohort in the Netherlands of chronic HIV infected patients within-depth reservoir characterization for future cure interventions. — 5-10 years The HIV latent reservoir will be characterised in chronic HIV patients using novel techniques like FISH-flow
To study the evolution of the HIV reservoir and immune host responses over time during antiretroviral therapy. — 5-10 years The HIV reservoir will be characterised over time to study the dynamics of the reservoir
Trial sites (1)
Facility
City
Region
Status
Erasmus MC
Rotterdam
Netherlands
More Erasmus Medical Center trials in the Netherlands
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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