CT scan: Patients undergoing CT scan staging for gastric and EJ junction cancer + perioperative chemotherapy (FLOT regimen) , CT scan re-staging and radical gastrectomy or esophagogastrectomy will be enrolled in the study
Study summary
The aim of this study is to develop a CT scan-based radiomics predictive model about tumor regression grade (TRG) in patients with esophago-gastric junction (EGJ) ang gastric cancer undergoing perioperative chemotherapy. The molecular expression of the neoplasms will be evaluated to assess its association with the TRG and the radiomic features.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients with histologically proven adenocarcinoma of the EGJ (Siewert II-III) or stomach.
* Preoperative staging: cT2-T4a, cN0-N3, M0.
* Patients \>18 years old.
* Patients undergoing perioperative chemotherapy with Docetaxel, oxaliplatin, leucovorin, and 5-fluorouracil (FLOT).
Exclusion Criteria:
* Siewert I EGJ tumor
* Patients undergoing preoperative radiotherapy.
* Absence of both pre and post-chemotherapy CT-scan.
* Patients with tumor progression during preoperative chemotherapy.
* Patients undergoing other neoadjuvant chemotherapy regimen different from FLOT
* Exploratory laparoscopy with positive cytology on the peritoneal lavage or evidence of peritoneal carcinosis
Primary outcome measure(s)
Predictive performance of radiomics analysis on the pre-treatment CT scan. — 2 months Comparing the radiomic features of the CT scans at the time of diagnosis (T0) and at the end of the preoperative chemotherapy (T1) in order to predict the TRG with the texture analysis on the first CT scan.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.
