The aim of Prevent CardioKids is to evaluate to what extend disturbed vascular function markers are already present in children of different weight categories and whether these are age dependent. Also differences - and relationships - between vascular function measurements and plasma biomarkers between lean and overweight/obese children will be compared.
Eligibility
Sex
ALL
Min age
6 Years
Max age
18 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Participation in the COACH program
* Aged between 6 and 18 years (at time of inclusion)
* Overweight or obesity according to IOTF criteria
In order to be eligible to participate in the control group, a subject must meet all of the following criteria:
* Aged between 6 and 18 years
* Normal weight according to the IOTF criteria
* Undergo surgery for elective reasons
Exclusion Criteria:
* Retarded children
* Children suffering from:
* Inflammatory diseases: auto-immune diseases, inflammatory bowel diseases, hepatitis, dermatitis, nephritis, pancreatitis, gastro-enteritis, vasculitis, salpingitis, arthritis, osteomyelitis, myositis, ear-nose-throat infections
* Allergic diseases: asthma, eczema, hay fever, food allergies
* Oncologic diseases
* Cystic fibrosis
* Type 1 diabetes mellitus
* Congenital metabolic diseases
* Malnourished children
Primary outcome measure(s)
Vascular function measured by peripheral arterial tonometry (EndoPAT) — 1 year The primary endpoint is the difference in micro- and macrovascular characteristics, as measured by EndoPAT in lean/overweight/obese children in different age groups.
Trial sites (1)
Facility
City
Region
Status
Maastricht University Medical Center
Maastricht
Limburg
Recruiting
More Maastricht University Medical Center trials in the Netherlands
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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