Effect of a Specialized Oral Supplement on Nutritional Status and Quality of Life in Non-dialysis CKD

Inclusion Criteria: * Patients over 18 years of age * Patients with diabetic kidney with eGFR \<60 ml / min / 1.73m2 and ≥15 ml / min / 1.73m2, (stage G3a, G3b and G4 respectively) * Patients with protein energy expenditure (defined by serum albumin \< 3.8 g/dl) * Patients with protein energy expenditure (defined by 24-hour recall less than a dietary protein intake \<0.6 g/kg/d or have a consumption \<25 kcal/kg/d * Patients who can read and write (or primary caregiver) * Domicile within the metropolitan area Exclusion Criteria: * Previous hospitalizations in the last month * Patients with serious complications (chronic infection, septicemia, cancer, HIV, Alzheimer's, uncontrolled heart failure, liver failure, cerebrovascular syndrome, malabsorption syndrome, or allergy to any ingredient in the nutritional supplement) * Patients with actual consumption of food supplements and / or keto analogues. Elimination Criteria: * Failure to attend nutritional assessment and biochemical testing at baseline, 2 months, and end of the study. * Failure to take the supplement \>10% (\>12 failed doses). * Diagnosis of any comorbidity during the intervention period. * Initiation of replacement therapy. * Identification of adverse effects. * Withdrawal of voluntary participation by the patient. * Death.