Active Comparator: Experimental: Active cathodal tDCS + language trainingSham Comparator: Placebo cathodal tDCS + Speech and language
Active Comparator: Experimental: Active cathodal tDCS + language training: Cathodal tDCS raises neuronal membrane potentials, leading to decreased probability of depolarization from incoming stimuli.
Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment.
Sham Comparator: Placebo cathodal tDCS + Speech and language: Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment. .
Study summary
62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.
Eligibility
Sex
ALL
Min age
25 Years
Max age
85 Years
Healthy volunteers
No
Inclusion Criteria:
1. aged 25-85
2. must be greater than 6 months post-stroke
3. must have a diagnosis of aphasia based on impaired performance on the Western Aphasia Battery-Revised, Boston Naming Test, or during discourse production
4. must be left-hemisphere dominant as demonstrated by aphasia onset subsequent to left hemisphere damage
5. must be stimulable for naming
Exclusion Criteria:
1. comorbid neurological disease.
2. damage to the anterior right hemisphere.
3. significant mood disorder.
4. substance/alcohol dependence or abuse within the past year
5. presence of any implanted electrical device or contraindications to tDCS or MRI
6. recent medical instability (within 4 weeks)
7. pregnancy
Primary outcome measure(s)
Picture Naming of trained items — 3 months Change in naming of pictures of trained items; 60 pictured items; higher score indicates improvement
Naming Response Time of trained items Scales - IV (WAIS-IV; Wechsler, Coalson, & Railford, 2008) — 3 months Change in response time of naming of pictures of trained items; 0-20 seconds, decreased response time indicates improvement Scales - IV (WAIS-IV; Wechsler, Coalson, \& Railford, 2008)
Naming Efficiency of trained items — 3 months Change in efficiency of naming of pictures of trained items; median response time divided by proportion correct naming; smaller numbers indicate greater efficiency
Trial sites (1)
Facility
City
Region
Status
University of New Mexico Center for Brain Recovery and Repair
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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