The purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Diagnosis of episodic (EM) or chronic migraine (CM) or CM with medication overuse headache (MOH) according to ICHD-III criteria;
* Age between 18 and 65 years;
* At least 2 migraine days (MMD) in the month preceding the inclusion;
* Migraine history of at least 12 months prior to inclusion
* Signed written informed consent.
Exclusion Criteria:
* History or current diagnosis of secondary headache disorders as defined by ICHD-III;
* History of other neurological comorbidities or major psychiatric disorders;
* History of migraine for \< 12 months prior to the inclusion;
* Opioid overuse according to the ICHD-III criteria;
* Pregnancy or breastfeeding.
Primary outcome measure(s)
Frequency of each symptom as the first premonitory symptom — Up to 6 months Premonitory symptoms will be recorded at the beginning of each migraine attack for a maximum of 5 migraine attacks per participant. For each premonitory symptom, the percentage of recorded attacks in which it was reported as the first symptom of the premonitory phase. Symptoms are recorded at headache onset for each attack via a structured electronic diary, capturing the type, sequence, onset, and duration of symptoms preceding the pain phase. The denominator is the number of recorded attacks with a premonitory phase.
Trial sites (1)
Facility
City
Region
Status
Sapienza University of Rome, Polo Pontino, centro cefalee, ICOT
Latina
Italy
Recruiting
More University of Roma La Sapienza trials in Italy
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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