Questionnaire: Each enrolled patient will complete quality of life questionnaires, specifically the EORTC QLQ-C30, PAN26, and EQ-5D, at different time points: at enrollment and every 2-3 months after surgery, for up to 2 years.
Study summary
Pancreatic cancer is a severe disease often diagnosed at an advanced stage, when surgery is not possible. New chemotherapy treatments can sometimes shrink the tumor and make surgery an option. This study aims to understand if surgery after such treatments can improve survival and quality of life in selected patients treated at expert centers.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients older than 18 years
* Patients able to give informed consent
* Histologically confirmed pancreatic adenocarcinoma
* LAPC stage according to NCCN10 at diagnosis (Figure 1)
* Received at least 4 months of induction chemotherapy
* RECIST 1.1 stable disease (SD) or partial response (PR) after induction therapy
* Patient considered eligible for radical resection by local MDT
Exclusion Criteria:
* Informed consent withdrawal
* Presence of tumor characteristics precluding surgery
* Presence of patient significant comorbidities precluding surgery
* Unavailable pre-induction therapy abdominal imaging
* Pathological confirmation of any tumor different from PDAC
Primary outcome measure(s)
HRQoL deterioration-free survival — From enrollment to the end of study period, set at 2 years The primary outcome is HRQoL deterioration-free survival, defined as the time from surgery until definite HRQoL score deterioration and including death from any cause as an event.
Trial sites (1)
Facility
City
Region
Status
UOC Chirurgia Generale 2, Azienda Ospedale di Padova, Padova, Italy 35128
Padova
Italy
Recruiting
More Azienda Ospedaliera di Padova trials in Italy
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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