Non-surgical periodontal therapy + sub-gingival air polishingNon-surgical periodontal therapy alone
Non-surgical periodontal therapy + sub-gingival air polishing: Participants receive a single session of non-surgical periodontal therapy (NSPT) using ultrasonic and manual instruments, combined with sub-gingival air polishing using erythritol powder. The treatment is applied to periodontal pockets with probing depth ≥ 4 mm in non-adjacent teeth.
Non-surgical periodontal therapy alone: Participants receive a single session of non-surgical periodontal therapy (NSPT) using ultrasonic and manual instruments.
Study summary
This clinical trial is studying whether using erythritol powder during non-surgical periodontal treatment (deep cleaning) helps improve gum health in people with severe periodontitis. Participants with deep gum pockets (4 mm or more) receive standard treatment alone or standard treatment plus cleaning with erythritol powder. The goal is to evaluate if adding erythritol improves outcomes such as healing of gum pockets, bleeding, plaque levels, and gum attachment compared to standard treatment alone.
Eligibility
Sex
ALL
Min age
35 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
Adults aged 18 years or older
Diagnosed with stage 3 or 4 periodontitis according to the 2017 classification
Presence of at least 12 natural teeth
Presence of periodontal pockets with probing depth ≥ 4 mm in non-adjacent teeth
Good general health or stable systemic conditions (e.g., controlled diabetes)
Exclusion Criteria:
Use of antibiotics or anti-inflammatory drugs within 3 months prior to treatment
Periodontal treatment in the previous 6 months
Pregnancy or breastfeeding
Current smokers of more than 10 cigarettes per day
Allergies or intolerance to erythritol or any materials used in the treatment
Systemic diseases or conditions that could influence periodontal healing (e.g., uncontrolled diabetes, immunodeficiency)
Use of medications known to affect periodontal tissues (e.g., phenytoin, cyclosporine, calcium channel blockers)
Primary outcome measure(s)
Proportion of periodontal pockets with successful pocket closure — 2 months and 4 months after treatment Percentage of treated periodontal pockets (with baseline probing depth ≥ 4 mm) that reach pocket closure, defined as probing pocket depth ≤ 4 mm without bleeding on probing, or ≤ 3 mm, at follow-up.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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