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Clinical Trials in Italy / NCT06832397
Starting soon Observational

Detection of Peritoneal Metastases by Diagnostic LAparoscopy in Patients With Locally Advanced Cervical Carcinoma

NCT06832397 · tracked via the Priya Life Science Italy tracker
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Phase
Observational
Started
2025-02
Last updated
2025-02-18

Condition(s) studied

Cervical Cancer

Investigational drug(s) / intervention(s)

Diagnostic laparoscopy

Diagnostic laparoscopy: Diagnostic laparoscopy with peritoneal biopsies

Study summary

The study hypothesizes that specific subgroups of LACC patients, (AJCC stage T3/T4, grade 3 tumors, and para-aortic lymph node involvement), have a higher prevalence of peritoneal metastasis. This peritoneal spread may serve as a prognostic factor, and diagnostic laparoscopy could improve staging accuracy, thereby guiding personalized treatment strategies and improving oncological outcomes.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Cervical cancer AJCC stage T3/T4 and/or * Cervical cancer FIGO stage IB3 and IIA2-IVA grade 3 and/or * Cervical cancer FIGO stage IIIC2 (para-aortic lymph node metastasis). Lymph node will be considered pathologic when the short axis diameter is \> 10 mm at MRI scan and/or SUV max \>2.5 at PET/CT-scan. * All cervical histology sub-types will be included * Stage assessment according to local Multidisciplinary Board * Age \>18 years * Signature informed consent or substitute declaration on the consent form where applicable. Exclusion Criteria: * Patients with previous diagnosis of other cancers * Performance status ECOG \>2 * Pregnant women * Contraindications to diagnostic laparoscopy * Recurrent cervical cancer

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Policlinico Agostino Gemelli IRCCS Rome Italy

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Other trials for the same condition

Therapeutic Effect of Surgical Debulking of Metastatic Lymph Nodes in Cervical Cancer Stage IIICr Recruiting
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20) Active, not recruiting
Implementation of Surgical Safety and Intraoperative Metastasis Identification Through Deep Learning: Multicentric Video Collection for Minimally Invasive Sentinel Lymph Node Dissection in Uterine Malignancies Recruiting
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22) Recruiting
Gut Microbiome in Patients With Lung and Melanoma Cancer and Intestinal Microbiota in Gynecologic Cancers Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06832397 on ClinicalTrials.gov ↗ ← All trials in Italy