The primary objective of the study will be to evaluate the possible association between asbestos exposure (occupational, paraoccupational, environmental and non-occupational) and pancreatic adenocarcinoma. The data collected will be used to generate specific hypotheses on the possible environmental and occupational determinants of the disease.
The study aims to evaluate:
1. To evaluate the exposure to asbestos occurred during life, through the use of a standardized questionnaire to be administered to incident cases (newly diagnosed) of histologically diagnosed pancreatic adenocarcinoma afferent to the Medical Oncology Unit Prof. Ardizzoni in Group A, the exposure to asbestos occurred during the course of life;
2. To produce quantitative estimates of the risk of pancreatic adenocarcinoma associated with asbestos exposure.
2.3. To evaluate the presence of asbestos fibers directly on histological sections of pancreatic cancer of patients exposed to asbestos and undergoing surgery.
Eligibility
Sex
ALL
Min age
30 Years
Max age
90 Years
Healthy volunteers
No
Group A
Inclusion Criteria:
1. Incident cases (new diagnosis) of histologically diagnosed pancreatic adenocarcinoma afferent to the Medical Oncology Unit Prof. Ardizzoni
2. Age 30-90 years
3. Ability to complete the questionnaire
4. Ability to read and understand Italian
5. Signing the informed consent form
Exclusion Criteria:
1\. Prevalent cases of the pathology under study
Group B
Inclusion Criteria:
1. Patients admitted to the S.Orsola-Malpighi Polyclinic in the ophthalmology, gynecology and urology departments with a diagnosis of cataracts, uterine fibroids and prostate adenoma previously included in the CARA study.
2. Age 30-90 years
3. Ability to complete the questionnaire
4. Ability to read and understand Italian
5. Signing the informed consent form
Exclusion Criteria:
1. Patients with pancreatic adenocarcinoma
2. Patients with a history of malignant neoplastic pathologies
3. Patients suffering from diseases associated with exposure to asbestos: pleuropatias (parietal plaques, diffuse visceral thickening, recurrent effusions and round atelectasis) and pulmonary diseases (alveolitis and asbestosis)
4. Patients in danger of life or hospitalized waiting to undergo surgery for pathologies other than those of inclusion
Primary outcome measure(s)
primary objective — From enrollment to the administration of the standardized questionnaire (once per patient), containing questions from the ReNaM (National Mesothelioma Registry) for up to 60 days. The primary objective of the study will be to evaluate the possible association between asbestos exposure (occupational, paraoccupational, environmental and non-occupational) and pancreatic adenocarcinoma. The data collected will be used to generate specific hypotheses on the possible environmental and occupational determinants of the disease.
Trial sites (1)
Facility
City
Region
Status
Irccs Aoubo
Bologna
Bologna
More IRCCS Azienda Ospedaliero-Universitaria di Bologna trials in Italy
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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