Positive Expiratory Pressure (PEP) and Continuous High-frequency Oscillation (CHFO) on Lung RECRUITment Using Electrical Impedance Tomography (EIT) - The PEP-RECRUIT Study

NCT06689020 · tracked via the Priya Life Science Italy tracker

Sponsor

University of Genova

Phase

Observational

Started

2024-12-01

Last updated

2024-11-14

Condition(s) studied

RecruitmentRespiratory Failure

Investigational drug(s) / intervention(s)

Continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy

Continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy: During application of CPEP and CHFO, EIT is monitored.

Study summary

This single-center observational study aims to assess the effects of continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy on lung recruitment using electrical impedance tomography (EIT) in spontaneously breathing patients admitted to the intensive care unit.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients who require pulmonary expansion and airway clearing as per clinical indication * Patients who provide valid informed consent according to local regulations * PaO2/FiO2 \< 200 mmHg at inclusion * Patient on the Airway Care Score (ACS) \< 7 Exclusion Criteria: * Refuse to participate * Age \< 18 years * Hemodynamic instability, defined as systolic arterial pressure \< 90 mmHg or mean pressure \< 60 mmHg * Contraindication to using an EIT (i.e., pacemaker or defibrillator) * Inability to properly position the EIT device for anatomical reasons

Primary outcome measure(s)

To assess changes in systemic oxygenation — Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment
Arterial partial pressure of oxygen (PaO2, mmHg) and PaO2/FiO2 ratio (mmHg)
Changes in lung recruitment using EIT — Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment
Absolute reduction in the percentage (%) of lung volume collapse assessed with the electrical impedance tomography (EIT)

Trial sites (1)

Facility	City	Region	Status
UO Clinica Anestesiologica e Terapia Intensiva, IRCCS Ospedale Policlinico San Martino	Genova	GE

Other trials for the same condition

SerpinB3 Expression, PAR2 and SCCA-PD Polymorphism in Acute Respiratory Distress Syndrome Recruiting

Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA Recruiting

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score Recruiting

The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients Recruiting

Quantification of Inspiratory Effort Through Nasal Pressure in Patients Undergoing Weaning From Invasive Mechanical Ventilation and Correlation With Clinical Outcomes Starting soon

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06689020 on ClinicalTrials.gov ↗ ← All trials in Italy