The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis.
Researchers will compare the effectiveness of the influenza vaccine in inducing protective antibodies between hemodialysis patients and subjects without chronic kidney disease.
Participants will:
* Be enrolled at the time of influenza vaccination
* Visit the clinic at 7, 14, 30, 60, and 120 days after vaccination
* Be asked to provide relevant clinical information and a blood sample at each visit
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Age between 18 and 70 years
* Patients undergoing thrice-weekly hemodialysis / peritoneal dialysis for at least 3 months OR healthy individuals without a history of renal insufficiency
* Subjects eligible to receive a seasonal influenza vaccine
* Signed informed consent for participation in the study
Exclusion Criteria:
* Recent influenza infection (clinically resolved less than 3 months ago).
* Administration of immunosuppressive drugs in the two weeks prior to vaccination.
* Administration of another vaccine in the three weeks prior to enrollment (co-administration of other vaccines with those under study does not contraindicate participation).
* Systemic infection clinically resolved less than two weeks before enrollment.
Primary outcome measure(s)
Frequency of serological response to influenza vaccination — From enrollment to 30±3 days after vaccination
Trial sites (3)
Facility
City
Region
Status
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan
Italy
Recruiting
ASST Santi Paolo e Carlo
Milan
Italy
Not Yet Recruiting
ASST Fatebenefratelli Sacco
Milan
Italy
Not Yet Recruiting
More Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico trials in Italy
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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