Prospective Multicenter Study on Mitral Annular Disjunction

Condition(s) studied

Investigational drug(s) / intervention(s)

diagnostic flow: exams to estimate the risk of adverse events in patients with MAD

Study summary

Observational cohort prospective multicenter study on patients with mitral annular disjunction (MAD). MAD is defined as a separation (≥1 mm) between the atrial wall-mitral valvular junction and the left ventricular free wall during end-systole

Eligibility

Primary outcome measure(s)

• Pathological findings associated with MAD — 3 months
  Percentage of subjects with MAD whom deeper analysis with cardiological visit, electrocardiogram (ECG), 24-hour ECG Holter monitoring and cardiac magnetic resonance (CMR) identifies pathological findings. Pathological findings are defined as follows: -T wave inversion in inferolateral leads at ECG * frequent premature ventricular complexes (\>1000/24h) * non-sustained ventricular arrythmias * sustained ventricular arrythmias * severe mitral regurgitation * myocardial fibrosis with a non-ischemic pattern, especially of papillary muscles and inferolateral wall. The primary endpoint will be considered achieved if at least one of the above mentioned paramentrs will be found in the patient

Trial sites (7)

More University Hospital of Ferrara trials in Italy

Other trials for the same condition