Sensory Rehabilitation in Chemo Induced Peripheral Neuropathy

Condition(s) studied

Investigational drug(s) / intervention(s)

Explicit Sensory Retraining for the lower extremities: Sensory retraining of detection, discrimination, quantification of a stimuli and recognition of stimuli and objects with the leg and mainly with the foot. Top-down awareness of bottom-up sensory experience in the treatment session and in everyday life.

no treatment: Usual care

Study summary

This study is a cross-over RCT evaluating the effectiveness of 3 sessions a week apart of explicit sensory retraining to the lower extremities in individuals with CIPN versus usual care. The primary outcome measures are TNAS for subjective symptoms, VAS for pain and TUG for mobility. Additional outcome measures are FABS for balance, sensory assessments - monofilaments for touch threshold, LEPT for proprioception, a home exercise log and a satisfaction questionnaire.

Eligibility

Primary outcome measure(s)

• Patient self-Report Outcome Measure - Treatment-Induced Neuropathy Assessment Scale (TNAS) — from randomization 3 months maximum
  TNAS -Treatment-Induced Neuropathy Assessment Scale: patient-reported outcome measure of presence and severity of CIPN. Nine 0-10 question scale. score 0-90. A higher score is for higher CIPN symptom severity.
• Functional - Balance and mobility outcome measure - Timed Up and Go test (TUG) — from randomization to maximum 3 months followup
  TUG -Timed Up and Go: Balance and mobility assessment. Serves as a fall prediction screening test. Measures time taken to raise from a chair walking 3 meters and re-sit.
• Pain intensity: VAS - 0-100 mm visual scale — from randomization to maximum 3 months
  Pain intensity: VAS - 0-100 mm visual scale: self-reporting pain assessment from no pain to worst pain possible. We will ask for current pain and the worst pain during the last week

Trial sites (1)

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