Blood test: Blood is collected in order to perform in vitro research:
1. If a routine blood test is performed for clinical tests, the sponsor will receive the results of the Complete blood count (CBC) and an additional blood sample from the same puncture of 20ml to maximum 40ml will be collected for this study.
2. If no routine blood test is performed for clinical tests, a CBC will be performed for the study and an additional blood sample of 20ml to maximum 40ml will be collected.
Additional Bone marrow (BM) material will be obtained from the same puncture performed for routine clinical tests:
Study summary
The study Objective is to collect samples of bone marrow aspirates and peripheral blood of patients with MDS for use in non-clinical research to investigate mitochondrial function sequence and effect of mitochondrial augmentation.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Male or female patients of 18 years old and up.
2. Suspected or previously diagnosed with Myelodysplastic Syndrome.
3. Patient able to understand and provide voluntary written informed consent.
Exclusion Criteria:
1\. History of prior allogeneic hematopoietic stem cell transplantation, cell therapy, gene therapy.
Primary outcome measure(s)
Investigate mitochondrial content and function in MDS patient-derived cells — 1 Year assays of mitochondrial content and function on whole bone marrow and HSPCs assays of hematopoietic lineages;
investigate effect of mitochondrial augmentation on MDS patient-derived cells — 1 Year in vivo studies of engraftment, biodistribution and function of augmented and/or non-augmented bone marrow aspiration and/or subpopulations of cells isolated from the bone marrow aspiration., in vitro ability to differentiate to various hematopoeitic lineages, immunophenotyping and single cells studies of cells post-augmentation and post-differentiation
Persistence of exogenous mtDNA after mitochondrial augmentation — 1 year Persistence of exogenous mtDNA after in vitro or in vivo culturing
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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