Improvement in Glycemic Response After Bariatric Surgery

NCT05325736 · tracked via the Priya Life Science Israel tracker

Sponsor

Weizmann Institute of Science

Phase

Observational

Started

2021-07-01

Last updated

2026-05-20

Condition(s) studied

Bariatric Surgery

Investigational drug(s) / intervention(s)

sleeve gastrectomy surgerygastric bypass surgerycontrolPancreatectomy

sleeve gastrectomy surgery: participants undergoing sleeve gastrectomy surgery

gastric bypass surgery: participants undergoing gastric bypass surgery

control: cholecystectomy

Pancreatectomy: Collecting a sample of an unidentified healthy pancreas to extract insulin-secreting beta cells from the sample

Study summary

decipher the role of microbiota in glycemic response change after bariatric surgery

Eligibility

Sex

ALL

Min age

18 Years

Max age

70 Years

Healthy volunteers

Accepted

Inclusion Criteria: * candidates of bariatric surgery or cholecystectomy * age 18-70 * male/female Exclusion Criteria: * previous bariatric surgery * type 1 diabetes * antibiotic treatment 3 months prior to the study * probiotic treatment 3 months prior to the study * chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders * any pathologic findings during endoscopy * participants who will suffer from a post-operation complication

Primary outcome measure(s)

Glycemic response — up to 4 years
The glycemic response will be measured by taking a blood test (glucose) after 12 hours fast and a second blood test (glucose) after an OGTT(oral glucose tolerance test) of 50 g glucose
microbiota composition — up to 4 years
The microbiota composition will be assessed using the stool samples of the participants.

Trial sites (2)

Facility	City	Region	Status
Weizmann Institute of Science	Rehovot	Israel	Recruiting
Souraski medical center	Tel Aviv	Israel	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05325736 on ClinicalTrials.gov ↗ ← All trials in Israel