Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study

NCT07760636 · tracked via the Priya Life Science France tracker

Sponsor

Assistance Publique - Hôpitaux de Paris

Phase

Observational

Started

2026-09

Last updated

2026-08-12

Condition(s) studied

Cardiac Arrest (CA)Intensive Care Unit (ICU) AdmissionReturn of Spontaneous CirculationComatose

Investigational drug(s) / intervention(s)

Value of neurofilament light chain (NFL) at different time points

Value of neurofilament light chain (NFL) at different time points: Value of neurofilament light chain (NFL) at different time points (H0, H12, H24, H48, H72, H96, and day 7 after ICU admission

Study summary

The purpose of this study is to assess the prognostic value of absolute value and kinetic of neurofilament light chain (NFL) collected at different time points (at admission, 12h, 24h, 48h, 72h, 96h, and day 7 after ICU admission) in predicting poor and good neurological outcome in comatose patients after cardiac arrest.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients admitted to the ICU for cardiac arrest, * Patients who regained consciousness following in-hospital or out-of-hospital cardiac arrest, * Patients in a coma upon arrival in the ICU, defined by a Glasgow Coma Scale (GCS) score \<8, * Patients included in the AfterROSC2 cohort, Exclusion Criteria: * Terminally ill patients (death expected within 3 hours of admission to the ICU), * Minors, * Patients under legal guardianship, * Pregnant women, * Patients not enrolled in a social security program, * Prior inclusion in the CINEFIL study, * Restriction of active therapies prior to the first NFL biomarker assay, * Objection by a family member or trusted person, if present

Primary outcome measure(s)

modified Rankin Scale (mRS) — 3 months
Neurological outcome assessed by the modified Rankin Scale (mRS) (An unfavorable outcome is defined as a modified Rankin Scale (mRS) score between 4 and 6 (severe neurological sequelae, persistent coma, or death), and a favorable outcome as a modified Rankin Scale (mRS) score between 0 and 3 (no sequelae, mild to moderate neurological sequelae))

Trial sites (1)

Facility	City	Region	Status
Medical ICU	Paris	IDF

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07760636 on ClinicalTrials.gov ↗ ← All trials in France