Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory.

NCT07585227 · tracked via the Priya Life Science France tracker

Sponsor

Direction Centrale du Service de Santé des Armées

Phase

Not applicable

Started

2026-05-06

Last updated

2026-05-13

Condition(s) studied

HypoxiaHypoxia BrainHypoxia Altitude Simulation TestHypoxia in Healthy IndividualsHypoxia, AltitudeHypoxia, BrainAltitudeAltitude HypoxiaNormobaric Hypoxia

Investigational drug(s) / intervention(s)

Hypoxia exposureOxygen administrationAir administrationStandardized cognitive tests (on a computer)Physiological measurementsBlood sample →Cognitive tests embedded in a flight simulator scenario

Hypoxia exposure: Normobaric hypoxia exposure (FiO2 = 12,6%, equivalent to 4,000m) during 4h

Oxygen administration: Oxygen administration (FiO2 = 100%) through a mask during 10 minutes

Air administration: Air administration (Fi02 = 21%) through a mask during 10 minutes

Standardized cognitive tests (on a computer): Auditory oddball, visual oddball, event-based prospective memory, time-based prospective memory, n-back.

Physiological measurements: EEG, ECG, SpO2, breathing rate, eyetracking, blood pressure

Blood sample: A blood sample is collected for mitochondrial breathing analyses

Cognitive tests embedded in a flight simulator scenario: Event-based prospective memory and time-based prospective memory. Prepar3D flight simulator.

Study summary

The goal of this study is to investigate whether prospective memory, i.e., memory for delayed intentions, is impaired at moderate altitude (4,000m).

It will also allow to study the effect of air and oxygen administration during hypoxia exposure.

The main questions it aims to answer are:

* Does moderate acute hypoxia impair prospective memory ?
* If so, does air or oxygen adminsitration induce a restoration of prospective memory? Researchers will compare cognitive performance during normobaric hypoxia exposure to cognitive performance during normoxia (control situation).

Participants will:

* Session S0. Perform a battery of neuropsychological tests and questionnaires). EEG will be recorded during tests. A cheek swab will be performed.
* Sessions S1 and S2. Perform several cognitive tasks while exposed to hypoxia and to normoxia (2 different sessions, randomized order) in a normobaric chamber. These are standardized cognitive tests administered on a computer and cognitive tests embedded in a flight simulator scenario. Various questionnaires will be performed on a regular basis. Several physiological measurements will be performed continuously: EEG, ECG, SpO2 and breathing rate. Blood pressure will be measured at the beginning and at the end of hypoxia/normoxia exposure. A blood sample will also be performed. At last, participants will inhale air or oxygen through a mask while making a cognitive task in the chamber.

Eligibility

Sex

ALL

Min age

18 Years

Max age

45 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Healthy volunteer * Has provided informed consent Exclusion Criteria: * Individuals who do not understand French * Pregnant or breastfeeding women * Cardiovascular risk factor * Infectious disease within the last 4 weeks * Chronic cardiovascular, respiratory, hematological, neurological, psychiatric, or metabolic disease * History of epileptic seizures, convulsions, or loss of consciousness * Individuals with migraines * History of a bleeding disorder * History of high blood pressure * Current medication use (excluding contraception) * History of episodes of altitude intolerance * Stay at high altitude (\> 3,500 m) within the last 3 months * Anxiety score on the Hospital Anxiety and Depression (HAD) scale \> 7 * Depression score on the HAD scale \> 7 * Uncontrollable claustrophobia or a history of panic attacks

Primary outcome measure(s)

Change in event-based prospective memory accuracy between hypoxia and normoxia conditions — Through study completion, an average of 1 month
Accuracy (%) = Prospective memory target detection rate (number of targets correctly responded to / total number of targets presented × 100)

Trial sites (1)

Facility	City	Region	Status
Institut de Recherche Biomédicale des Armées	Brétigny-sur-Orge	France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07585227 on ClinicalTrials.gov ↗ ← All trials in France