The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of stimulation. The main hypotheses are:
* NDD participants and children exhibit higher intra-individual variability than other participants
* intra-individual neurophysiological variability is correlated to behavioral, psychological and learning profiles
Participants in this study will:
* be recorded for EEG and other neurophysiological parameters while exposed to sensory stimulations, to quantify sensory neurophysiological variability
* perform behavioral tests and fill out questionnaires, to establish the behavioral and psychological profile
* train for perceptual learning, to measure learning abilities
These evaluations will be split in 3 visits spread on a maximum of 3 months, and training for learning will be done at home in between 2 visits.
Eligibility
Sex
ALL
Min age
6 Years
Max age
45 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Social security affiliation
* Free and written informed consent from the participants (Neurotypical Adults, NDD Adults without judicial protective measures), or their tutor or legal representant(s) (other participants)
* Age between 6 and 12 years included (Children) or between 18 and 45 years included (Adults)
* For NDD participants: NDD diagnosis by a qualified medical professional, according to DSM-4, DSM-5, ICD-10 or ICD-11 criteria
Non-inclusion Criteria:
* Psychotropic medication perturbing EEG recording
* Drugs pertubing peripheral neurophysiological measures
* Non-corrected visual or auditory troubles
* Known neurological or psychiatric conditions (at the exclusion of NDD for NDD participants)
* Epilepsy
* Inclusion in another ongoing medical protocol
* For Neurotypical participants: NDD diagnosis
* For NDD participants: anticipated psychological or physical risk at participating, at the investigator's discretion
Exclusion Criteria:
* Participants with no data to evaluate Outcome 1
Primary outcome measure(s)
Amplitude of central neurophysiological responses to sensory stimulations — Through study completion, an average of 2 months per participant Amplitude (in micro-volts) of event-related potentials
Latency of central neurophysiological responses to sensory stimulations — Through study completion, an average of 2 months per participant Latency (in milli-seconds) of event-related potentials
Variability of central neurophysiological responses to sensory stimulations — Through study completion, an average of 2 months per participant Intra-individual variability (in percentage) of event-related potentials
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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