Non-interventionnal study: Non-interventionnal study
Study summary
The main objective is to assess the effect of increased PEEP on echo-Doppler venous congestion in ARDS patients at two PEEP levels, by grading congestion in each venous flow (suprahepatic, renal, portal) as "absent," "moderate," or "severe," and also calculating the VExUS score.
Eligibility
Sex
ALL
Min age
18 Years
Max age
99 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients hospitalized in the Medical Intensive Care and Hyperbaric Medicine Unit of Angers University Hospital, receiving mechanical ventilation in assist-control mode (A/C ventilation), and presenting with ARDS as defined by the following criteria (1):
* Hypoxemia with a PaO₂ (mmHg)/FiO₂ (0.21 to 1.0) ratio \<300 mmHg with a positive end-expiratory pressure (PEEP) ≥5 cmH₂O;
* Pulmonary edema not fully explained by cardiac failure or fluid overload;
* Presence of bilateral pulmonary opacities on chest imaging not fully explained by pleural effusions, atelectasis, or pulmonary nodules.
Exclusion Criteria:
* Minor patient (\<18 years old)
* ECMO (Extracorporeal Membrane Oxygenation)
* Hemodynamic instability (mean arterial pressure \<60 mmHg)
* Respiratory instability (SpO₂ \<90% under FiO₂ \>90%)
* Severe organic tricuspid regurgitation
* Congenital heart disease
* Pneumothorax
* Renal or hepatic transplant recipient
* Liver cirrhosis Child-Pugh C
* Portal vein thrombosis or Budd-Chiari syndrom
* Abdominal compartment syndrome documented by intra-abdominal pressure ≥20 mmHg
* Pregnant, breastfeeding, or peripartum women
* Persons deprived of liberty by judicial or administrative decision
* Persons subject to compulsory psychiatric care
* Persons under legal protective measures
Primary outcome measure(s)
Evolution of the level of venous congestion evaluated on the different abdominal Doppler venous flows (portal, suprahepatic and renal venous Doppler) and on the VExUS score between the different levels of PEEP (high and low) — Baseline The evolution of venous congestion between two PEEP levels (high and low), assessed by analyzing each Doppler flow individually (hepatic veins, renal interlobar veins, and portal vein) and grading them as 'absent,' 'moderate,' or 'severe,' as well as by the VExUS score, graded from 0 to 3.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.