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Clinical Trials in France / NCT07452952
Starting soon Observational

Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.

NCT07452952 · tracked via the Priya Life Science France tracker
Phase
Observational
Started
2026-03-01
Last updated
2026-03-05

Condition(s) studied

Mechanical VentilationAcute Respiratory Distress Syndrome (ARDS)

Investigational drug(s) / intervention(s)

Non-interventionnal study

Non-interventionnal study: Non-interventionnal study

Study summary

The main objective is to assess the effect of increased PEEP on echo-Doppler venous congestion in ARDS patients at two PEEP levels, by grading congestion in each venous flow (suprahepatic, renal, portal) as "absent," "moderate," or "severe," and also calculating the VExUS score.

Eligibility

Sex
ALL
Min age
18 Years
Max age
99 Years
Healthy volunteers
No
Inclusion Criteria: * Patients hospitalized in the Medical Intensive Care and Hyperbaric Medicine Unit of Angers University Hospital, receiving mechanical ventilation in assist-control mode (A/C ventilation), and presenting with ARDS as defined by the following criteria (1): * Hypoxemia with a PaO₂ (mmHg)/FiO₂ (0.21 to 1.0) ratio \<300 mmHg with a positive end-expiratory pressure (PEEP) ≥5 cmH₂O; * Pulmonary edema not fully explained by cardiac failure or fluid overload; * Presence of bilateral pulmonary opacities on chest imaging not fully explained by pleural effusions, atelectasis, or pulmonary nodules. Exclusion Criteria: * Minor patient (\<18 years old) * ECMO (Extracorporeal Membrane Oxygenation) * Hemodynamic instability (mean arterial pressure \<60 mmHg) * Respiratory instability (SpO₂ \<90% under FiO₂ \>90%) * Severe organic tricuspid regurgitation * Congenital heart disease * Pneumothorax * Renal or hepatic transplant recipient * Liver cirrhosis Child-Pugh C * Portal vein thrombosis or Budd-Chiari syndrom * Abdominal compartment syndrome documented by intra-abdominal pressure ≥20 mmHg * Pregnant, breastfeeding, or peripartum women * Persons deprived of liberty by judicial or administrative decision * Persons subject to compulsory psychiatric care * Persons under legal protective measures

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
University Hospital of Angers Angers France

More University Hospital, Angers trials in France

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07452952 on ClinicalTrials.gov ↗ ← All trials in France