Interest of Adaptated Physical Activity (APA) on the K Recovery Constant, Reflecting the Rate of Muscle Oxygenation Recovery in Menopausal Women Suffering From Depression
Depression - Major Depressive DisorderMenopausal Depression
Investigational drug(s) / intervention(s)
APACCATTP
APA: 3 sessions/week of APA (1h yoga, 1h dance, 1h muscle strengthening)
CCATTP: 2 sessions/week of 2 hours art therapy. This approach is already used in routine healthcare and is not a procedure specific to the study.
Study summary
APhyDeM is a randomized controlled study investigating the relationship between adapted physical activity and mitochondrial function in postmenopausal women with major depressive disorder.
Depression is associated with metabolic dysfunction, including alterations in mitochondrial activity and inflammatory processes. Physical activity has been shown to influence mitochondrial function, yet individuals with depression frequently experience reduced physical activity levels.
This study aims to evaluate whether an adapted physical activity program can improve mitochondrial function compared with a control intervention. Mitochondrial function will be indirectly assessed using near-infrared spectroscopy to measure post-exercise muscle oxygen recovery kinetics.
The study compares adapted physical activity with a non-physical therapeutic intervention in postmenopausal women receiving care in a psychiatric day hospital setting.
Eligibility
Sex
FEMALE
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Menopaused women aged ≥ 40 years old,
* Suffering from a major depressive episode according to international Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-V)
* Presenting a score ≥11 on the 16-item Quick Inventory of Depressive Symptomatology Clinician Rating (QIDS-C16) depression scale
* With a stabilized teatment by antidepressors since at least 4 weeks
Exclusion Criteria:
* Medical contraindication for physical activity (cardio-vascular pathology, and/or previous cardiac disease)
* Asthma or other unstabilized condition impairing the ability to perform physical exertion
* Adipose tissue thickness measured on the forearm \> 12 mm causing muscle oxygenation measurement by NIRS to be non contributive
Primary outcome measure(s)
K recovery constant — Week 8 Relative difference of K recovery constant (min-1) reflecting the recovery speed of muscular oxygenation, assessed with muscular near-infrared spectroscopy (NIRS) at week 8, comparing with pre-randomization value.
This measure is assessed at rest and following mitochondrial activation by MOTOmed15 movement therapy.
Trial sites (1)
Facility
City
Region
Status
CHU de Besançon
Besançon
France
More Centre Hospitalier Universitaire de Besancon trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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