Study of Skin and Gut Microbiome in a Skin Condition Involving Skin Barrier Impairment and Allergic Symptoms: Netherton Syndrome

Condition(s) studied

Investigational drug(s) / intervention(s)

Superficial skin swabs: Sampling areas: (18 swabs in total + 6 swabs for routine skin mapping) 1. Lesion area outside skin folds (e.g., back or limb) 2. Healthy area outside skin folds (e.g., back or limb) 3. Perioral area of the face 4. Scalp 5. Inguinal fold 6. Axillary fold

Superficial skin swabs: Three superficial skin swabs: same locations as for Netherton patients

Stool samples: A stool sample collected for analysis of the fecal microbiome and mycobiome.

Saliva samples: A saliva sample collected for analysis of the saliva microbiome and mycobiome.

Blood samples: For group A: cytokine profile from an additional blood sample taken during a blood draw for treatment For group B: cytokine profile if there is any residual blood sample from the treatment

Blood samples: For group A: cytokine profile from an additional blood sample taken during a blood draw for treatment For group B: cytokine profile if there is any residual blood sample from the treatment

Data-Collection: Socio-demographic data and lifestyle habits of the patient and parents

Data-Collection: Clinical data, treatment data, and results of biological tests carried out as part of routine monitoring

Study summary

It is proposed to conduct an exploratory study to analyze the skin, intestinal, and salivary microbiome, as well as the skin mycobiome and virome, of patients (adolescents and young adults) with Netherton syndrome, a condition characterized by an impaired skin barrier that most likely promotes the development of allergic manifestations.

The study will be conducted on patients with Netherton syndrome and control subjects in order to investigate possible correlation factors between the three microbiomes and identify which ones.

Eligibility

Primary outcome measure(s)

• Study of the skin, salivary and intestinal microbiota — Baseline
  Analyse the skin microbiome, mycobiome, and virome, as well as the intestinal and salivary microbiome of patients with Netherton syndrome in comparison with healthy controls.

Trial sites (1)

More Assistance Publique - Hôpitaux de Paris trials in France

Other trials for the same condition