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Clinical Trials in France / NCT07189624
Starting soon Not applicable

Effect of Acute Endurance Exercise on the Production of FGF21 and Follistatin in Patients With Hepatocellular Carcinoma

NCT07189624 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Clermont-Ferrand
Phase
Not applicable
Started
2025-12
Last updated
2025-12-31

Condition(s) studied

Cirrhosis With Hepatocellular Carcinoma

Investigational drug(s) / intervention(s)

Exercise

Exercise: 30-minutes exercise on a bicycle with heart rate monitor and gas exchange analyzer.

Study summary

The main purpose of the study is to characterize the production of hepatokines (FGF21 and Follistatin) in response to a submaximal exercise on an ergocycle, in patients with hepatocellular carcinoma. The effect of exercise on hepatokines and metabolites production in liver cancer patients is not known. Studying this production could help to provide relevant recommendations for training programming in these patients.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * Hepatocellular carcinoma developed on cirrhosis * Cirrhosis of any etiology, defined by a liver elasticity measurement \>15kPa or a history of cirrhosis decompensation * Hepatocellular carcinoma with indication for treatment by immunotherapy or chemoembolization * Child-Pugh scores A and B7 * WHO score ≤ 2 * Affiliation to french national social security system Exclusion Criteria: * Hepatic encephalopathy grade II or higher * Bone metastasis * Surgery performed within 30 days prior to inclusion visit * Liver transplant * Muscle injury within 3 months of inclusion * Pregnant or breast-feeding women * Patients under legal protection (guardianship, curatorship, safeguard of justice) * Participation in another clinical trial within 10 days of inclusion

Primary outcome measure(s)

Trial sites (2)

FacilityCityRegionStatus
Chu Estaing Medecine Digestive Et Hepatobiliaire Clermont-Ferrand France
CHU de Clermont-Ferrand Clermont-Ferrand France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07189624 on ClinicalTrials.gov ↗ ← All trials in France