Recommendation from the infectious diseases team: No commercial product was evaluated in this study. We are assessing the benefits and consequences of a change in clinical practice implemented at the hospital level. At our institution, it is now recommended that TBE serology be performed in all cases of undocumented meningitis or meningoencephalitis.
The infectious diseases team at our hospital simply advises the clinicians responsible for patient care to perform this test.
Study summary
Tick-borne encephalitis (TBE) is a viral infection transmitted by ticks. TBE is the third most common cause of encephalitis in France. Across France, numerous cases of lymphocytic meningitis remain without a definitive diagnosis, notably at the Nancy University Hospital. The objective of this study is to assess the impact of a change in diagnostic practice on the work-up of undocumented lymphocytic meningitis and meningoencephalitis at Nancy University Hospital.
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Individuals who have received full information regarding the organisation and conduct of the study
* Adults or children
* Hospitalised in a department of Nancy University Hospital with a diagnosis of lymphocytic meningitis or meningoencephalitis
* Cerebrospinal fluid showing more than 5 cells/mm³, with either a negative FilmArray result or no FilmArray performed
Exclusion Criteria:
* Patients diagnosed with non-lymphocytic meningitis or meningoencephalitis
* Patients with documented lymphocytic meningitis or meningoencephalitis of a known cause (excluding TBE) prior to the date the advisory was issued
* Patients who have expressed opposition to the use of their data for this study
Primary outcome measure(s)
TBE diagnosis — This study compares data from the pre-intervention period (2022-2024) with that from the post-intervention period (2024-2026). To measure the impact of revised diagnostic procedures on TBE detection among cases of unexplained clear-fluid meningitis and meningoencephalitis at Nancy University Hospital.
Trial sites (1)
Facility
City
Region
Status
University Hospital of Nancy, Brabois Hospital
Vandœuvre-lès-Nancy
Lorraine
More Central Hospital, Nancy, France trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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