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Clinical Trials in France / NCT07160959
Starting soon Not applicable

Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions

NCT07160959 · tracked via the Priya Life Science France tracker
Sponsor
Biogem s.c.ar.l
Phase
Not applicable
Started
2026-01-01
Last updated
2025-09-08

Condition(s) studied

Chronic Kidney Disease (Stages 4 and 5)Mild Cognitive Impairment (MCI)

Investigational drug(s) / intervention(s)

ExerciseControl (Standard treatment)

Exercise: Patients will undergo a home-based low-intensity interval multi component exercise program including aerobic and strengthening exercise

Control (Standard treatment): Patients will be treated with standard therapy based on their CKD stage

Study summary

This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems. The study includes a clinical trial where patients will either receive standard care or follow a home-based exercise program involving walking and strength training, to see if regular physical activity can improve brain function. It also includes a large-scale analysis of data from the UK Biobank to explore blood and genetic markers, brain imaging, and lifestyle factors linked to cognitive health. The ultimate aim is to find effective, easy-to-implement strategies and early warning signs that could lead to better treatment and quality of life for people living with CKD.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * CKD at KDOQI stage 4-5 * concomitant MCI (MOCA - MMSE (17 \< MoCA \< 26) or (16 \< MMSE \< 24) Exclusion Criteria: * Absolute contraindication to exercise training (e.g. unstable angina, major amputation, severe heart failure, etc.) * Known life expectancy \< 6-month * Uncorrected anemia (Hb \<9 g/dl) * Non-provision of informed consent

Primary outcome measure(s)

Trial sites (6)

FacilityCityRegionStatus
Assistance Publique - Hôpitaux de Paris (AP-HP), Division of Geriatry Paris France
Biogem Ariano Irpino Italy
Lithuanian University of Health Sciences Kaunas Lithuania
University Medical Center Groningen, Department of Nephrology Groningen Netherlands
Medical University of Warsaw, Department of Nephrology, Dialysis and Internal Medicine Warsaw Poland
University of Zurich Zurich Switzerland

Other trials for the same condition

Prospective Analysis of Self Medication With Phytotherapy in Nephropatic Patients. Recruiting
Assessment of Protein Intake Using 2 Types of Nutritional Collection in Chronic Kidney Disease. Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07160959 on ClinicalTrials.gov ↗ ← All trials in France