RVU120: RVU120 is a potent, selective inhibitor of CDK8 and its paralog CDK19
Ruxolitinib: Selective inhibitor of the Janus Associated Kinases (JAKs) JAK1 and JAK2
This is a multicenter rollover study to provide continued treatment to eligible participants previously enrolled in a RVU120 clinical study and to evaluate the safety of the treatment and record the time on treatment when continued under the same regimen as in the parent study.
To be eligible for this rollover study, participants must be continuing to benefit from their treatment, show an acceptable safety profile, and not have access to commercially available comparator anticancer therapy. Once transitioned to this study, participants will continue with their next planned dose per the regimen of their parent study.
| Facility | City | Region | Status |
|---|---|---|---|
| Hôpital l'Archet 1 - CHU de Nice; Service Hématologie Clinique | Nice | France | |
| Hôpital Haut-Lévêque- CHU de Bordeaux, Centre François Magendie, Service d'Hématologie Clinique et Thérapie Cellulaire | Pessac | France | |
| M2M Med Sp. Z o.o. | Chorzów | Poland | |
| CWBK UCK Ośrodek Badań Klinicznych Wczesnych Faz | Gdansk | Poland | |
| Pratia Hematologia Sp. z o.o. Pratia Onkologia Katowice | Katowice | Poland | |
| SPZOZ Szpital Uniwersytecki w Krakowie | Krakow | Poland | |
| Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Terapii Komórkowych i Chorób Wewnętrznych | Wroclaw | Poland |
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06987058 on ClinicalTrials.gov ↗ ← All trials in France