Involvement of Archaea in Carious Disease

NCT06787261 · tracked via the Priya Life Science France tracker

Sponsor

Assistance Publique Hopitaux De Marseille

Phase

Not applicable

Started

2026-02-19

Last updated

2026-02-23

Condition(s) studied

Dental Caries

Investigational drug(s) / intervention(s)

saliva samplecarious tissue samples

saliva sample: saliva sample

carious tissue samples: carious tissue samples

Study summary

Dental caries is a major public health probleme the result of hard tissue demineralization and oral microbiota changes.

Methanogenic archaea, mainly Methanobrevibacter oralis, are associated with various oral problems, including pathologies periodontal.

Previous research has not really studied the Archaea in carious lesions, hence the importance of our study.

Our study aims to explore their potential role in the the development of caries by analysing their prevalence and their quantification in relation to the carious risk individual. The aim is to improve understanding of the Cavity microbiology to advance management of this pathology in terms of prevention or of treatment.

Our team is particularly competent in the field of Archaea, especially in the cultivation of Archaea methanogens since we have a dedicated platform. We also discovered the first human Nanoarchaea, opening up a whole new possible search field.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Male or female of legal age. * Patient who is a beneficiary or entitled beneficiary of a social security * Patient under the care of the Restorative and Preventive Dentistry of the PROMOD - Timone Dentistry Unit. * Patients capable of giving written consent. Exclusion Criteria: Patient in a period of exclusion from another research protocol at the time of signing the consent form, Subjects covered by articles L1121-5 to 1121-8 of the Public Health public health code (minor patients, patients of full age under guardianship, patients deprived of their liberty, pregnant or breast-feeding), A person who does not have a sufficient command of reading and understanding of the French language to be able to consent to take part in the research Presence of periodontitis (gingivitis not being a criterion for a criterion for non-inclusion). Antibiotics taken in the previous month. Use of mouthwash in the previous 7 days.

Primary outcome measure(s)

Presence/absence of Archaea in participants' saliva samples. — 36 months

Trial sites (1)

Facility	City	Region	Status
Asssistance Publique Hopitaux de Marseille	Marseille	France	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06787261 on ClinicalTrials.gov ↗ ← All trials in France