Evaluation of the Reproducibility of the Automated Measurement of the Extent of ILD on Chest CT

NCT06743022 · tracked via the Priya Life Science France tracker

Sponsor

Assistance Publique - Hôpitaux de Paris

Phase

Not applicable

Started

2025-06-24

Last updated

2026-09-22

Condition(s) studied

Interstitial Lung Disease

Investigational drug(s) / intervention(s)

Chest CT

Chest CT: Repeated chest CT for automated ILD quantification

Study summary

In interstitial lung disease (ILD), the extent of ILD on chest computed tomography (CT) is recognized as an important prognostic factor. Automated tools are now available to quantify ILD, but there is a lack of data on the reproducibility of this measurement and therefore its accuracy.

Therefore, the purpose of this study is to evaluate the variability of automated ILD quantification on chest CT. Reproducibility will be assessed by repeating chest CT scans and using different tools to measure the extent of disease.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age ≥ 18 years * Known interstitial lung disease as part of idiopathic pulmonary fibrosis or connective tissue disease * Followed in one of the participating hospitals * Requiring a chest CT as part of a scheduled assessment * Affiliated to a French national social security * Informed consent Exclusion Criteria: * Acute exacerbation of ILD * Pregnancy * Inability to hold an apnea for 10 seconds * Patients in the exclusion period after a previous research * Need for additional procubitus or expiratory images

Primary outcome measure(s)

Automated Interstitial Lung Disease (ILD) quantification — Day of inclusion
Reproducibility of ILD quantification on chest CT (as a percentage of lung volume) between two successive scan acquisitions.

Trial sites (6)

Facility	City	Region	Status
APHP - Bichat hospital - Radiology	Paris	IDF	Recruiting
APHP - Bichat hospital - Rheumatology	Paris	IDF	Recruiting
APHP - Cochin Hospital - Internal medicine	Paris	IDF	Recruiting
APHP - Cochin Hospital - Pneumology	Paris	IDF	Recruiting
APHP - Cochin Hospital - Radiology	Paris	IDF	Recruiting
APHP - Bichat Hospital - Pneumology	Paris	IDF	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06743022 on ClinicalTrials.gov ↗ ← All trials in France