Identification of Molecular Signatures of High-risk Oncogenic HPV and Study of Their Associations With the Presence of High-grade Lesions and/or Anal Cancer 10 Years After Inclusion in the ANRS IPERGAY Trial
High-resolution anoscopy: The study includes 2 visits:
* a medical consultation for inclusion
* a proctology consultation including the performance of an AHR associated or not with biopsy sampling
Study summary
HPVsign is a cross-sectional, non-comparative, multicenter study involving all participants included in the HPV substudy of the ANRS IPERGAY trial. The study proposes to evaluate the cumulative incidence of high-grade lesions and/or anal cancers using high-resolution anoscopy (HRA) during the HPVsign study and/or diagnosed since the end of participation in the ANRS IPERGAY trial.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* Participant in the ANRS IPERGAY clinical trial who was included in the initial HPV sub-study;
* Informed and written signed consent
* Participant with regular health insurance
Exclusion Criteria:
* Participant under guardianship or curatorship
* Participant with free State medical assistance
* Participant who disagrees with the use of data collected as part of their participation in the ANRS IPERGAY trial.
Primary outcome measure(s)
High-Grade Squamous Intraepithelial Lesion (HSIL) and/or anal cancers diagnosed by an high-resolution anoscopy (HRA) — Within the 10 years prior to HPV sign study participation, or at the study proctological examination in the study.
Trial sites (3)
Facility
City
Region
Status
Hôpital de la Croix Rousse - SMIT
Lyon
France
Recruiting
Hôpital Saint-Louis - SMIT
Paris
France
Recruiting
Hôpital Tenon - SMIT
Paris
France
Recruiting
More ANRS, Emerging Infectious Diseases trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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