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Clinical Trials in France / NCT06478303
Recruiting Observational

LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension

NCT06478303 · tracked via the Priya Life Science France tracker
Phase
Observational
Started
2024-07-27
Last updated
2026-10-02

Condition(s) studied

Corticospinal ExcitabilityCortical Activation

Investigational drug(s) / intervention(s)

Motor imageryAction readingMotor localizer

Motor imagery: Participants were asked to imagine arm or foot movements.

Action reading: Participants were asked to read sentences involving arm or foot movements

Motor localizer: Participants were asked to perform arm or foot movements

Study summary

Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.

Eligibility

Sex
ALL
Min age
18 Years
Max age
40 Years
Healthy volunteers
Accepted
Inclusion Criteria: * persons who have given written consent, * healthy subjects * subjects reading and understanding French * right-handed, * affiliated with a social security system, * between 18 and 40 years old, * had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study. Exclusion Criteria: * Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous, * Regular use of anxiolytics, sedatives, antidepressants, neuroleptics, * Characterized psychiatric pathology, * Ingestion of alcohol prior to the examination, * Persons covered by articles L1121-5 to L1121-8 of the CSP, * Presence of contraindications to MRI or TMS.

Primary outcome measure(s)

Trial sites (2)

FacilityCityRegionStatus
CHU Grenoble Alpes Grenoble Grenob Recruiting
Université de Bourgogne Dijon France Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06478303 on ClinicalTrials.gov ↗ ← All trials in France