increase of mean arterial pressure at 65-70 mmHgincrease of mean arterial pressure at 80-85 mmHg
increase of mean arterial pressure at 65-70 mmHg: Increase of mean arterial pressure at 65-70 mmHg (with catecholamines or volemic expansion at the discretion of the clinician)
increase of mean arterial pressure at 80-85 mmHg: Increase of mean arterial pressure at 80-85mmHg (with catecholamines or volemic expansion at the discretion of the clinician).
Study summary
The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adult patients (≥ 18 years old )
* Arterial hypotension requiring the etablishment of catecholamines
* Norepinephrine dose ⩾ 0.1µg/kg/min at the inclusion
* High central venous pressure ≥ 12mmHg
* Cardiac output monitoring (PICCO or Swan Ganz)
Exclusion Criteria:
* Anuria
* Patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH \<7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration \> 40 mmol/l)
* Pregnant, lactating or parturient woman
* Patient deprived of liberty by judicial or administrative decision
* Patient with psychiatric compulsory care
* Patient subject to legal protection measures
* Patients with do-no-reanimate order or withdrawal of life sustaining support
Primary outcome measure(s)
Changes of creatinine clearance — At 6 hours and at 12 hours Creatinine clearance is calculated with the formula UV/P as follow :
* U being the urinary creatinine concentration in μmol/l
* V the urinary volume expressed in ml per unit time
* P the plasmatic creatinine concentration in μmol/l
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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