* Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
* Describing immuno-inflammatory profiles associated with massive vascular leakage during those three forms of circulatory failure in humans
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Informed consent from patient or a legal representative/family member/close relative. The patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow.
2. Affiliation to social security (AME excluded)
3. Patient with one of the circulatory failures described below:
* septic shock
* cardiogenic shock
* post-resuscitation syndrome
* Cardiogenic shock:
* Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND
* Cardiac index \<2 L/min/m2 or left ventricular ejection fraction (LVEF)\<35%, AND
* Lactate \>2.0 mmol/l
* Post-resuscitation syndrome:
* Cardiac arrest (absence of spontaneous respiration, palpable heartbeat, and responsiveness to stimuli\> 1 min) with a compatible electrocardiogram (asystole/pulseless electrical activity/ventricular tachycardia), AND
* Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND
* Lactate \>2.0 mmol/l
* Septic shock:
* Suspected or proven bacterial infection
* Need for a vasopressor support to maintain mean arterial pressure\>65 mmHg
* Lactate \>2.0 mmol/l
* Cardiac index\>3L/min/m2 or LVEF\>40%
Exclusion Criteria:
1. Onset of shock (catecholamine infusion) \>12 hours prior to inclusion
2. Age \<18 year old
3. Pregnancy
Primary outcome measure(s)
Fluid balance from Day 0 to day 3 — Between Day 0 and Day 3 (ml/kg of initial body weight). The fluid balance, routinely monitored in ICU, represents fluid intakes (perfusion, oral intakes,..) - fluid losses (diuresis, diarrhea,…)
Trial sites (1)
Facility
City
Region
Status
Hôpital Européen Georges Pompidou
Paris
France
Recruiting
More Assistance Publique - Hôpitaux de Paris trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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