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Clinical Trials in France / NCT05378841
Recruiting Not applicable

Efficacy of Surgical Joint Denervation in Painful Digital Osteoarthritis

NCT05378841 · tracked via the Priya Life Science France tracker
Phase
Not applicable
Started
2023-06-05
Last updated
2025-07-14

Condition(s) studied

Osteoarthritis Hand

Investigational drug(s) / intervention(s)

Surgical Denervation

Surgical Denervation: This is an outpatient procedure performed under local anesthesia (depending on the anesthesiologist's decision), which lasts about 30 minutes.

Study summary

Digital osteoarthritis is the second localization of symptomatic osteoarthritis, after the knee. Its cardinal symptoms are particularly intense pain and functional impairment in the case of the erosive form. There is currently no etiological treatment for osteoarthritis. Symptomatic treatments have a modest efficacy, which justifies the search for new treatments. The surgical options are arthrodesis or prosthesis, invasive techniques potentially sources of complications, and finally proposed infrequently given the prevalence of digital osteoarthritis.

DECAD is a prospective phase II trial aimed at evaluating the efficacy of surgical joint denervation in painful digital osteoarthritis.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥ 18 years * Patients with symptomatic digital osteoarthritis according to the criteria of the American College of Rheumatology * 1 painful PIP joint (Analog digital scale ≥ 4/10) for more than 3 months * having failed the usual medical treatment for a minimum of 3 months (level 1 analgesics, NSAIDs, infiltrations) * Signature of informed consent * patient affiliated to a social security scheme * knowing how to read French (for the questionnaires) Exclusion Criteria: * digital osteoarthritis secondary to other known causes (eg gout, reactive arthritis, RA, psoriatic arthritis, spondyloarthropathies, septic arthritis) * anesthetic contraindications to surgery or to performing an MRI * Existence of a pain syndrome in the upper limbs, which would interfere with the assessment of AD. * Fibromyalgia * Use of oral, intramuscular or intra-articular or intravenous corticosteroids, immunosuppressants (methotrexate, sulfasalazine, leflunomide, biomedicines), hyaluronic acid infiltration in the finger joints in the previous month * Introduction of a new treatment for osteoarthritis of the hand in the previous month, including physiotherapy and fitting of a new finger orthosis. * History of denervation of the proximal interphalangeal joint (PIP) * Patient under legal protection (guardianship or curatorship) and patient deprived of liberty * Patient under AME * Participation in another interventional research involving the human person or period of exclusion at the end of a previous research involving the human person.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Rheumatology department Saint-Antoine Hospital Paris France Recruiting

More Assistance Publique - Hôpitaux de Paris trials in France

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05378841 on ClinicalTrials.gov ↗ ← All trials in France