Audiological and vestibular testsBlood samplingneurocognitive self-questionnaire
Audiological and vestibular tests: 6h of audiological and vestibular tests divide in 3 sessions :
* Session A : objective audiological tests
* Session B ; subjective audiological tests
* Session C : balance tests.
Blood sampling: A 10 mL blood sample will be collected during the study.
neurocognitive self-questionnaire: Four self-questionnaires to fill out to measure sleep quality, memory and emotional state
Study summary
Age-related hearing loss, or presbycusis, is caused by many genetic and environmental factors. Its prevalence poses a public health challenge of early identification and effective hearing aid treatment. However, the lack of screening and of a validated audiological test battery to diagnose an individual's needs and to guide hearing aid adjustments is a major obstacle.
Furthermore, monogenic forms of hearing loss affect only one functional module of hearing. The audiological test(s) dependent on the function of this module are affected, in a progressive manner, but not the others. A previous study showed that in early onset presbycusis patients, a quarter of the subjects tested were affected by monogenic presbycusis.
The collection of audiological and vestibular tests, carried out on proven monogenic presbycusis patients and compared to that of normal hearing patients, would constitute a battery of tests allowing a precision diagnosis, then developed to all forms of presbycusis in order to study if the identification of abnormal functional modules can usefully guide the diagnosis and the early fitting.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
For all participants:
* Be over the age of 18,
* Be affiliated to a social security system,
* Have a good command of the French language (oral and written).
For the group of participants with anticipated presbycusis:
* Over the age of 40, having a hearing aid recipient or coming for a first hearing aid recipient
* Between 18 and 40, having a hearing aid recipient, coming for a first hearing aid recipient or declare a progressive genetic birth defect
For healthy volunteers:
\- Have no known hearing loss.
Exclusion Criteria:
* Report having been chronically exposed to loud sounds.
* Have a history of ototoxic substances,
* To have sequelae of ear infections and/or a history of ENT disease that permanently affects hearing or balance,
* Have an ethnic origin for which the Pasteur Institute does not have information on the frequency of variants of the genes studied.
* Have type II diabetes,
* Have a neurological or psychiatric condition that interferes with comprehension or ability to move,
* Be under guardianship,
* Be deprived of liberty by judicial or administrative decision, or be subject to legal protection,
* Not being subject to a social security system,
* Taking narcotic substances, alcohol or medication that diminishes cognitive abilities.
Primary outcome measure(s)
Measurement of specificity and sensitivity of the audiological test battery in participants with early-onset presbycusis after identification of pathogenic variants by sequencing and division into subgroups. — 2 years specifity and sensitivity will be calculated to identify which tests or combinations of audiological and vestibular tests will be the most discriminating in characterizing each functional module of hearing from participants with monogenic forms of presbycusis of anticipated onset, each affecting a determined functional module, in comparison with an age-matched control group.
Trial sites (2)
Facility
City
Region
Status
Laboratoire de correction auditive
Paris
France
Not Yet Recruiting
CEntre de Recherche et d'Innovation en Audiologie Humaine
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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