Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease

NCT05227547 · tracked via the Priya Life Science France tracker

Sponsor

Centre Hospitalier Intercommunal Creteil

Phase

Not applicable

Started

2022-10-05

Last updated

2025-09-02

Condition(s) studied

Chronic Obstructive Lung DiseaseChronic Obstructive Pulmonary Disease

Investigational drug(s) / intervention(s)

Thoracic resection surgery

Thoracic resection surgery: Patients undergoing thoracic resection surgery (pneumonectomy, lobectomy, segmentectomy) for cancer or suspected cancer, including smokers (active or ex-smokers) and non-smokers, with COPD and without COPD, and non-smoking patients.

Study summary

To evaluate the regenerative capacities of mesenchymal cells composing the microenvironment of alveolar type 2 cells in a population of patients, undergoing thoracic surgery for suspected cancer, who are smokers with and without COPD compared to non-smokers patients

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. Age ≥ 18 2. Patient undergoing lung resection surgery (lobectomy, pneumonectomy, segmentectomy) for cancer or suspected cancer 3. Acceptance to participate in the protocol 4. Affiliated to a social security plan Exclusion Criteria: 1. Chronic autoimmune disease 2. Patient under guardianship or curators 3. Neo-adjuvant chemotherapy 4. History of thoracic radiotherapy 5. Pregnant woman 6. Minor patient 7. Person not able to consent 8. Person deprived of liberty

Primary outcome measure(s)

Number of alveolar organoids — through study completion, an average of 3 years
Comparison of the number of alveolar organoids formed 21 days after culture of fibroblasts with alveolar type II cells between smokers with and without COPD and non-smoking patients

Trial sites (4)

Facility	City	Region	Status
Rousseau-Bussac	Créteil	France	Recruiting
Hopital Cochin	Paris	France	Active Not Recruiting
HEGP	Paris	France	Active Not Recruiting
Hopital Tenon	Paris	France	Active Not Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05227547 on ClinicalTrials.gov ↗ ← All trials in France