The Medical Management in Patients Exposed to Weapons of Mass Destruction

NCT05026645 · tracked via the Priya Life Science France tracker

Sponsor

St. Justine's Hospital

Phase

Observational

Started

2020-10-01

Last updated

2025-10-01

Condition(s) studied

Chemical InjuryChemicals; IntoxicationAcute Respiratory Distress SyndromeDistress Respiratory SyndromeMedical Emergencies

Investigational drug(s) / intervention(s)

Clinical interventions performed in acute settings (contaminated environment)Protection (clinician and patient)Decontamination (clinician and patient)

Clinical interventions performed in acute settings (contaminated environment): Any clinical intervention performed on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic).

Protection (clinician and patient): As interrelated competence of the clinical intervention, any protection procedure and capability applied on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic). Concerning the clinician, the protection implied for his/her own safety and for the patient to whom she/he was in closed/contact with.

Decontamination (clinician and patient): As interrelated competence of the clinical intervention and protection, any decontamination procedure and capability applied on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic). Concerning the clinician, the protection implied for his/her own safety and for the patient to whom she/he was in closed/contact with. This crucial step is usually expected prior the patient's transfer into a clean zone like the emergency room or its equivalent.

Study summary

Observation study measuring medical response in contaminated environment.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Inclusion Criteria: i. a CBRNE attack caused at least one casualty who required the assistance of the participating health care system (e.g.: physicians, nurses, paramedics and other health-care specialists of a medical facility) during a medical extraction from the incident site until admission to a medical facility; ii. Patients are eligible if they were exposed to the CBRNE attack; iii. Medical information concerning the CBRNE exposures, even if partial, is accessible to health care professionals for the purposes of filling out the online case report form (eCRF); iv. Participants must be able to complete the online case report form in English; and v. The approval of an Ethics Review Board is obtained by each medical centre participant. Exclusion Criteria: A negative response to any of the inclusion criteria results in an exclusion.

Primary outcome measure(s)

Intervention and location — At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).
The percentage of patients to whom the World Health Organization's healthcare guidelines were applied without any delay (i.e.: during a medical extraction/evacuation)

Trial sites (15)

Facility	City	Region
Director, Unconventional Weapons & Technology Division, National Consortium for the Study of Terrorism and Responses to Terrorism University of Maryland	College Park	Maryland
Centre for Defence and Security Studies, University of Manitoba	Winnipeg	Manitoba
Royal Canadian Medical Corps	Ottawa	Ontario
École de Technologie Supérieure Université du Québec	Montreal	Quebec
Research Center of the CHU St-Justine, University of Montreal	Montreal	Quebec
Research Centre, Quebec Heart and Lung Institute, Laval University	Québec	Quebec
Medical Intelligence CBRNE Inc.	Québec	Quebec
Biomedical Telematics Laboratory Platform of the Quebec Respiratory Health Research Network	Sherbrooke	Quebec
University of Finance and Administration Department of Criminology and Forensic Disciplines	Prague	Prague
Sorbonne University	Paris	Île-de-France Region
Tokyo Women's Medical University, Department of Intensive Care Medicine	Tokyo	Shinjuku-ku
Department of Critical care, Miyagi Children's Hospital	Tokyo	Japan
Department of Disaster Medical Management, The University of Tokyo Hospital	Tokyo	Japan
Surrey and Sussex Healthcare NHS Trust	Surrey Quays	Redhill
CBRNE World Journal	Winchester	United Kingdom

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05026645 on ClinicalTrials.gov ↗ ← All trials in France