specimen sample collection: Before and during treatment, and at progression, collection of :
* Blood
* Exhaled air
* Saliva
* Sweat
* Tears
* Urine
Study summary
This is a monocentric cohort study, prospective and interventional with minimal risks and constraints for advanced breast cancer. The planned interventions are collection of biological samples at different times. The study will aim to do a descriptive analysis of omics profiles evolution (tumor, volatile organic components) over time, before and after disease progression under Palbociclib treatment with a clinical-biological database.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Women over 18 years old
* With histologically proven breast cancer, positives hormones receptors and negative HER2
* Advanced disease (metastases or non-resequable locoregional disease), from the 1st to the 4th line.
* With an indication for hormone therapy associated with the CDK4/6 inhibitor Palbociclib
* Agree to the sampling of the study
* Signed the informed consent form
Exclusion Criteria:
* Neoadjuvant or adjuvant treatment for localized breast cancer
* Metastatic breast cancer beyond the forth line
* Impossibility to give informed consent (person deprived of liberty or under guardianship)
Primary outcome measure(s)
Intrapatient variation in molecular profiles at progression compared to baseline — From date of inclusion until the date of first documented progression (around 2 years) Variation over time in the rate of VOCs in response to treatment and in progression situations.
longitudinal changes in VOCs profile and exosomes according to response to treatment — From date of inclusion until the date of first documented progression, assessed up to 2 years variation over time in exosomes count in response to treatment and in progression situations
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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