dMRI, fMRI and electrocorticography: Patients included in the study will perform the pre-operative MRI (fMRI and fMRI) with a specific High Resolution Angular Diffusion (HARDI) sequence and a functional rest sequence. The additional scan time for this specific sequence is approximately 25 minutes, with no foreseeable negative impact on the patient
Study summary
In this pilot study, the investigators propose a multimodal evaluation of the brain connectivity of brain tumor patients, in order to better understand the effects induced by focal lesions on brain structure and function, as well as brain plasticity mechanisms that may occur in such condition. The investigators aim at drawing a multimodal brain connectivity map of focally brain-damaged patients, with a view to improve onco-functional neurosurgical practices.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* All patients with brain tumor for removal
* Age \> 18 years
* Informed patient consent
* Membership of social security scheme
Exclusion Criteria:
* Contraindication to MRI
* Any subject with vascular stent implanted less than 6 weeks prior to the exam;
* Any subject carrying an intraocular or intracranial ferromagnetic foreign object close to nerve structures;
* Any subject carrying biomedical equipment such as a cardiac, neuronal or sensory pacemaker (cochlear implant) or a ventricular bypass valve without medical and paramedical supervision trained in the performance of MRI in these subjects;
* Presence of more than one brain tumor
* Refusal of patient participation
* Pregnant or nursing women. A urinary pregnancy test will be conducted for women of childbearing age. The results will be communicated to the patient by a doctor of her choice.
* Person staying in a health or social establishment
* Person in emergency situation
* Vulnerable patient: deprived of liberty, guardianship, curators, or safeguarding of justice
Primary outcome measure(s)
Correlations between tumor topography, cortical electrical conduction rates measured in electrocorticography, and microstructural measurements of white substance from diffusion MRI — 1 month
Trial sites (1)
Facility
City
Region
Status
CHU de Nice
Nice
CHU de NICE
More Centre Hospitalier Universitaire de Nice trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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