Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries

Condition(s) studied

Investigational drug(s) / intervention(s)

Ketorolac: After confirmation of circulatory isolation of the operated limb by the inflated tourniquet, 30 mg ketorolac tromethamine diluted in normal saline in a total volume of 50 ml will be injected

Control: After confirmation of circulatory isolation of the operated limb by the inflated tourniquet, 50 ml normal saline without drugs will be injected

Study summary

Tourniquet, a compressing device, otherwise its use in intravenous regional anesthesia, is commonly used in particular orthopedic surgeries. From the previous documented effectiveness and safety of intravenous (IV) administration of ketorolac in the circulatory-isolated limb as a part of intravenous regional anesthesia; we hypothesized that in orthopedic surgeries done with tourniquet, intravenous (IV) administration of ketorolac after tourniquet inflation, will act as intravenous regional analgesia. So, it will prolong the postoperative analgesic duration as a primary outcome.

Eligibility

Primary outcome measure(s)

• The postoperative analgesic duration — within 24 hours after the surgery
  the time measured from the onset of spinal anesthesia to the first request of analgesia by the patient

Trial sites (1)

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