Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate

Condition(s) studied

Investigational drug(s) / intervention(s)

left atrial appendage closure: systematic closure of the left atrial appendage in addition to the planned heart surgery

Study summary

The purpose of the project is to elucidate whether it is possible to identify which patients are at risk of forming blood clots that can cause stroke based on analysis of the electrocardiogram.

In connection with the operation, the small pouch known as the auricle of the heart is closed, which can be completely removed after closing. This procedure is common in patients with atrial fibrillation to protect the brain from stroke. In the project, all patients will have this auricle closed if they agree to participate in the project.

After closure, the auricle is usually discarded. We will analyze the blood and the auricle tissue taken (if available) in connection with the operation itself, together with the analysis of the electrocardiogram recorded before the planned heart operation.

Eligibility

Primary outcome measure(s)

• stroke — six years
  number of patients with clinical stroke

Trial sites (1)

More University Hospital Bispebjerg and Frederiksberg trials in Denmark

Other trials for the same condition