inducement of experimental pain: Inducement of experimental pain
Study summary
Study comparing pain intensity and discomfort in patients with Parkinson´s disease and healthy controls during inducement of mechanical, thermal, and chemical experimental pain
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
Accepted
Inclusion criteria
* Group healthy volunteers: healthy subjects with no PD diagnosis
* Group PD patients levodopa: Include PD patients treated with levodopa
* Group PD patients DBS: Include PD patients with DBS Exclusion criteria
* Known other neurological or medical disorders (e.g., stroke, neuropathy, diabetes) or other disorders with expected influence on experimental pain
* Known dementia (a score \<24 on the MoCA)
* Known untreated depression (a score ≥15 on the Beck Depression Inventory)
* Unable to cooperate
* Treated with painkillers except paracetamol and NSAID (except if pain and treatment is ad-equately stable as evaluated by a doctor)
Primary outcome measure(s)
Thermal induced heat pain — Immediately after assessment of ongoing pain (15 minutes) Thermal heat detection and pain thresholds will be measured following the standardized "Quantitative Sensory Testing" protocol
Mechanical induced pain — Immediately after assessment of thermal induced heat pain (15 minutes) Mechanical pain thresholds and suprathresholds will be measured by use of a handhold pressor algometer (Somedic, Hörby, Sweden) with a 1-cm2 probe placed on test muscle (gluteus medius muscle, tibialis anterior muscle, and infraspinatus muscle in a randomized order)
Chemical induced pain — Immediately after assessment of mechanical pain (15 minutes) Chemical pain will be induced by an injection of hypertonic saline (HS, 5,8% in 1 ml)
Ongoing pain (Clinical pain in daily life) — After assessment of motor response latencies measure (15 minutes) Intensity and discomfort of ongoing pain in gluteus medius muscle, tibialis anterior muscle, and infraspinatus muscle will be assessed by use of 11- point Numeric Rating Scale (NRS)
Ongoing pain (Sensory and affective verbal descriptions of pain and patient drawings) — After assessment of motor response latencies measures (15 minutes) Sensory and affective verbal descriptions of pain and patient drawings of pain size and distribution will be measured by use of the short-form McGill Pain Questionnaire (SF-MPQ).
Ongoing pain (Pain in PD) — After assessment of motor response latencies measures (15 minutes) Pain in PD will be assessed by King´s Parkinson´s disease pain scale (KPPS)
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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