Effectiveness of Family-based Intervention for Youn Persons With Eating Disorders

Condition(s) studied

Investigational drug(s) / intervention(s)

Family-based treatment: Open-end family therapy ad modum The Maudsley model

Study summary

This research project aims to characterize a naturalistic cohort of children and adolescents with eating disorders in terms of biological, psychological and psychopathological features. Further, the project will examine the effectiveness of treatment, the determinants of treatment outcome and the course of treatment response for children and adolescents with eating disorders (ED), treated in a generic specialist child and adolescent mental health service. The first choice of treatment is outpatient family-based treatment (FBT), which has documented effect for anorexia nervosa and bulimia nervosa. However, a subgroup of young persons with eating disorders does not respond sufficiently to this treatment, and evidence concerning effective treatment for children and adolescents with atypical eating disorders is still lacking. Further, treatment effectiveness for children and adolescents in a Danish naturalistic setting has never been examined.

Eligibility

Primary outcome measure(s)

• proportion of participants with weight normalisation — through treatment completion an average of 1 year
  at or above 95% of ideal BMI adjusted for age and gender, based on the individual´s prior growth trajectory. BMI is calculated as weight in kg/(height in meters\*height in meters), and percentage if ideal BMI adjusted for age and gender is based on published, standardized growth curves from Danish children and adolescents
• proportion of participants with weight normalisation — 2.5 years after treatment completion
  at or above 95% of ideal BMI adjusted for age and gender, based on the individual´s prior growth trajectory. BMI is calculated as weight in kg/(height in meters\*height in meters), and percentage if ideal BMI adjusted for age and gender is based on published, standardized growth curves from Danish children and adolescents
• proportion of participants with weight normalisation — 5 years after treatment completion
  at or above 95% of ideal BMI adjusted for age and gender, based on the individual´s prior growth trajectory. BMI is calculated as weight in kg/(height in meters\*height in meters), and percentage if ideal BMI adjusted for age and gender is based on published, standardized growth curves from Danish children and adolescents
• proportion of participants with weight normalisation — 7.5 years after treatment completion
  at or above 95% of ideal BMI adjusted for age and gender, based on the individual´s prior growth trajectory. BMI is calculated as weight in kg/(height in meters\*height in meters), and percentage if ideal BMI adjusted for age and gender is based on published, standardized growth curves from Danish children and adolescents
• proportion of participants with weight normalisation — 10 years after treatment completion
  at or above 95% of ideal BMI adjusted for age and gender, based on the individual´s prior growth trajectory. BMI is calculated as weight in kg/(height in meters\*height in meters), and percentage if ideal BMI adjusted for age and gender is based on published, standardized growth curves from Danish children and adolescents
• proportion of participants with absence of eating disordered behaviors — through treatment completion an average of 1 year
  absence for 4 weeks (according to diagnostic questions if Eating Disorder Examination (EDE).
• proportion of participants with absence of eating disordered behaviors — 2.5 years after treatment completion
  absence for 4 weeks (according to diagnostic questions if Eating Disorder Examination (EDE).
• proportion of participants with absence of eating disordered behaviors — 5 years after treatment completion
  absence for 4 weeks (according to diagnostic questions if Eating Disorder Examination (EDE).
• proportion of participants with absence of eating disordered behaviors — 7.5 years after treatment completion
  absence for 4 weeks (according to diagnostic questions if Eating Disorder Examination (EDE).
• proportion of participants with absence of eating disordered behaviors — 10 years after treatment completion
  absence for 4 weeks (according to diagnostic questions if Eating Disorder Examination (EDE).

Trial sites (1)

More Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital trials in Denmark

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