Cognitive Function After Radiation Therapy for Primary Brain Tumours

NCT04306432 · tracked via the Priya Life Science Denmark tracker

Sponsor

University of Aarhus

Phase

Observational

Started

2019-01-03

Last updated

2021-12-02

Condition(s) studied

Primary Brain TumourRadiation ToxicityCognitive Impairment

Investigational drug(s) / intervention(s)

Cognitive tests and Patient Reported Outcomes

Cognitive tests and Patient Reported Outcomes: Each patient will undergo cognitive tests and questionnaires

Study summary

This study will assess cognitive function in patients with a primary brain tumour treated with radiation therapy (RT) to generate radio-sensitivity and volume effect parameters for the development of cognitive dysfunction. All types of brain tumours apart from glioblastoma will be included.

Eligibility

Sex

ALL

Min age

18 Years

Max age

100 Years

Healthy volunteers

Accepted

Inclusion Criteria: * 18 years or older and Danish speaking. * Performance status WHO 0-2 * Capable of cooperating on testing * Tumour histology (WHO 2016 classification) of the following types: anaplastic astrocytoma (IDH mutant), diffuse astrocytoma (IDH-mutant), gemistocytic astrocytoma (IDH mutant), diffuse astrocytoma (NOS), oligodendroglioma, meningioma, medulloblastoma (NOS), pituitary adenoma, other brain tumours including skull base sarcomas Exclusion Criteria: * Glioblastoma * Performance status 3-4 (Karnofsky Performances of 60 or less)

Primary outcome measure(s)

Impairment of verbal learning and memory as assessed by the HVLT-r test — 10 Years
Examined by the Hopkins Verbal Learning Test revised. It will be correlated to the mean radiation dose to the hippocampus. Outcome is number of correct words (0-24)

Trial sites (5)

Facility	City	Region	Status
Department of Oncology, Rigshospitalet	Copenhagen	Capital Region	Recruiting
Danish Center for Particel Therapy	Aarhus	Region Midt	Recruiting
Department of Oncology, Aarhus University Hospital	Aarhus	Region Midt	Recruiting
Department of Oncology, Aalborg University Hospital	Aalborg	Region Nord	Recruiting
Department of Oncology, Odense University Hospital	Odense	Region Syd	Recruiting

More University of Aarhus trials in Denmark

Inflammation's Impact on Heart Disease and Diabetes Recruiting

Cystic Fibrosis in the Kidney: Monitoring the Effectiveness of Elexacaftor/tezacaftor/ivacaftor in Urine After a Short Pause of Therapy Recruiting

Hyperpolarized 129-Xenon MRI in Fibrosing Interstitial Lung Disease Active, not recruiting

Efficacy of Solifenacin, Mirabegron and Combination Therapy in Children With Daytime Urinary Incontinence (BeDry) Recruiting

Reinnervation and Neuromuscular Transmission in ALS Recruiting

Other trials for the same condition

Shared Decision Making on Radiation Dose for Lung Malignancies Active, not recruiting

Optimized Rehabilitation of Older Adults With Hip Fracture and Signs of Cognitive Impairment - Feasibility Study Recruiting

COr Loco-regional Advanced Lung Cancer Treated With Chemo-radiotherapy (COLA) Recruiting

Cognitive Function in Melanoma Patients Treated With Adjuvant Immune Checkpoint Inhibitors Active, not recruiting

Curatively Intended Thoracic Reirradiation Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04306432 on ClinicalTrials.gov ↗ ← All trials in Denmark