Postoperative Pain After Total Knee ArthroplastyPostoperative PainAnalgesic Consumption
Study summary
This prospective observational study evaluates postoperative pain intensity and analgesic consumption in patients undergoing total knee arthroplasty (TKA) under different anesthesia techniques. Patients receive either general anesthesia with peripheral nerve block, spinal anesthesia with peripheral nerve block, spinal anesthesia alone, or general anesthesia with an epidural catheter. Pain scores (NRS), analgesic use, adverse effects, patient satisfaction, and the need for therapeutic interventions are assessed during the first 48 hours after surgery. The study aims to identify differences in postoperative pain control and factors associated with hypotension and other complications.
Eligibility
Sex
ALL
Min age
18 Years
Max age
100 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Age 18-100 years
* Primary total knee arthroplasty (TKA)
* ASA physical status I-III
* Glasgow Coma Scale (GCS) score of 15
* Ability to understand study procedures and provide informed consent
* Ability to cooperate during pre-anesthetic evaluation
* No severe sensory impairment (e.g., blindness, deafness)
Exclusion Criteria:
* Revision or reoperation of TKA
* ASA score IV or higher
* Refusal to participate or inability to provide informed consent
* GCS ≤ 14
* Limited legal capacity
* Active psychiatric disorder
* Chronic use of strong opioid analgesics
* Neurological disease affecting pain perception or cooperation
* Cognitive impairment or language barrier preventing questionnaire completion
* Use of anesthesia techniques other than GA + PNB or SA + PNB (e.g., epidural anesthesia, local infiltration without PNB)
Primary outcome measure(s)
Postoperative pain intensity — 6 hours, 24 hours, and 48 hours after surgery Pain intensity will be assessed using the Visual Analog Scale (VAS) or Numerical Rating Scale (NRS) at predefined postoperative intervals. Both scales range from 0 to 10, where 0 indicates no pain and 10 indicates the worst pain imaginable.
Higher scores represent worse pain intensity.
Trial sites (1)
Facility
City
Region
Status
Tomas Bata regional hospital
Zlín
Czechia
More Tomas Bata Hospital, Czech Republic trials in Czechia
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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