High resolution oesophageal manometry with impedance24-hour pH metry
High resolution oesophageal manometry with impedance: Patients with extraoesophageal reflux and dysphagia will undergo high resolution oesophageal manometry with impedance.
24-hour pH metry: Patients with extraoesophageal reflux will undergo 24-hour pH-metry.
Study summary
The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution manometry with impedance and 24-hour pH-impedance monitoring.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* age 18-75 years
* patients with swallowing difficulties suspected of having a functional oesophageal disorder or patients with clinical signs of extra-oesophageal reflux (Reflux Symptom Index \[RSI\] ≥ 13 or Reflux Symptom Score-12 \[RSS-12\] ≥ 11) signed informed consent
Exclusion Criteria:
* patients with a diagnosed tumor of the esophagus or upper airway, or with strong clinical suspicion of a tumor of the esophagus or upper airway
* severe neurological disease affecting swallowing
* pregnancy
* surgery involving the head, neck, or esophagus within the last 6 months
Primary outcome measure(s)
PAET (Proximal Acid Exposure Time) — 24 hours PAET (Proximal Acid Exposure Time) - acid exposure to the proximal oesophageus will be measured in per cent of the whole 24-h period.
Upper esophageal sphincter (UES) Integrated Relaxation Pressure (IRP) — 15 minutes UES IRP is a measure of the extent of UES relaxation measured in mmHg
UES Maximum Admittance — 15 minutes UES MaxAd is the highest admittance value recorded during trans-sphincteric bolus flow measured in milliseconds.
Trial sites (1)
Facility
City
Region
Status
University Hospital Ostrava
Ostrava
Moravian-Silesian Region
More University Hospital Ostrava trials in Czechia
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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