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Clinical Trials in Canada / NCT05442463
Recruiting Observational

Hormone Therapy and Angiotensin-Dependent Arterial and Renal Vasoconstriction in Humans

NCT05442463 · tracked via the Priya Life Science Canada tracker
Sponsor
University of Calgary
Phase
Observational
Started
2020-11-30
Last updated
2025-03-27

Condition(s) studied

Hormone Therapy

Investigational drug(s) / intervention(s)

Captopril Tablets →Iohexol →

Captopril Tablets: Captorpril challenge to each participant

Iohexol: Iohexol infusion to evaluate measured GFR

Study summary

1. to investigate the association between route of administration of exogenous estrogen (transdermal vs. oral) and cardiorenal risk in cisgender (gender identity aligning with sex at birth) and transgender (gender identity not aligning with sex at birth) women.
2. to investigate the association between exogenous testosterone exposure and cardiorenal risk in cisgender (gender identity aligning with sex at birth) and transgender (gender identity not aligning with sex at birth) men.

Eligibility

Sex
ALL
Min age
18 Years
Max age
90 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Age 18 to 90 years * Taking hormones orally or non-orally (either estrogen, progesterone or testosterone) Exclusion Criteria: * Cardiovascular disease (symptoms consistent with myocardial ischemia, previously documented myocardial ischemia, cardiac arrhythmias or valve abnormalities, or abnormal ECG at screening) * Cerebrovascular disease (transient ischemic attacks or stroke) * History of hypertension (BP\>140/90 or use of antihypertensive medications) * Estimated glomerular filtration rate (eGFR) \< 60 ml/min/1.73m2 * Diabetes mellitus (defined by history, use of hypoglycaemic agents or a fasting glucose \>7mmol/L) * Current smoker * Previous history of preeclampsia * Anabolic steroids, cortical steroids, or non-steroidal anti-inflammatory medications, or at the discretion of the investigator.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
University of Calgary Calgary Alberta Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05442463 on ClinicalTrials.gov ↗ ← All trials in Canada