Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer

NCT05314400 · tracked via the Priya Life Science Canada tracker

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Phase

Not applicable

Started

2022-07-01

Last updated

2025-07-11

Condition(s) studied

Liver Metastasis Colon Cancer

Investigational drug(s) / intervention(s)

Full Gadoxetate-enhanced liver MRIShortened Gadoxetate-enhanced liver MRI

Full Gadoxetate-enhanced liver MRI: Standard pulse sequences

Shortened Gadoxetate-enhanced liver MRI: Fewer pulse sequences

Study summary

After a patient is diagnosed with colon cancer, they receive a CT of the chest, abdomen, and pelvis to see if the cancer has spread (metastasized) to other parts of the body. A common site for the cancer to spread to is the liver. If an abnormality is seen in the liver on CT, sometimes an MRI of the liver is required to determine a) whether it is cancer or not and b) whether there are small tumours in the liver that were not visible on CT.

During the MRI, the patient is injected with intravenous (IV) contrast. This makes liver lesions more conspicuous and also helps determine if they are cancerous or not. The most commonly used IV contrast agent is called Gadovist. However, there is another IV contrast agent called Primovist that is better at detecting liver metastases from colon cancer than Gadovist. This is very important information for surgeons, because if they considering cutting out (resecting) the liver tumours, they want to make sure they get them all.

Unfortunately, Primovist is used sparingly in Canadian hospitals because it is more expensive than Gadovist and the MRI takes longer. Some early small studies have suggested that it may be possible to shorten the Primovist MRI significantly (e.g. from 60 minutes to 15 minutes), making it economically feasible to offer Primovist to more patients. However, there have not been any large studies performed to confirm these findings.

The purpose of this study is to compare the accuracy of colon cancer liver metastasis detection between a regular, full-length Primovist MRI versus a shortened Primovist MRI protocol. The economic impact will also be assessed.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Male or female, 18 years of age or older * Diagnosis of colorectal cancer, biopsy proven * Prior imaging showing liver lesions that may be metastases * Provision of signed and dated informed consent form * Willingness to comply with study procedures and availability for the duration of the study * Able to tolerate MRI required by protocol Exclusion Criteria: * Presence of implanted medical device or metallic object that is MR incompatible * Baseline eGFR of \< 30 mL/min/1.73 m2 * Severe claustrophobia not relieved by oral anxiolytics * Documented severe allergic-like reaction gadolinium-based contrast agent * Weight greater than allowable on MRI table * Pregnancy * Diffuse liver metastases, i.e. definitively unresectable * Severe liver dysfunction, ALBI grade 3

Primary outcome measure(s)

Diagnostic accuracy of abbreviated versus full MRI protocol — 2 years
Sensitivity, specificity, area under ROC curve

Trial sites (2)

Facility	City	Region	Status
St. Joseph's Healthcare	London	Ontario	Recruiting
London Health Sciences Centre	London	Ontario	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05314400 on ClinicalTrials.gov ↗ ← All trials in Canada